Molecular structure of Chaetoglobosin F, CAS Number: 55945-75-0
Chaetoglobosin F (CAS 55945-75-0)
Alternate Names:
(21,22-Dihydro,19-ketone,20β-alcohol)-chaetoglobosin A
CAS Number:
55945-75-0
Molecular Weight:
530.7
Molecular Formula:
C32H38N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Chaetoglobosin F is a mycotoxin that functions as a potent inhibitor of protein synthesis. It exerts its mechanism of action by binding to the eukaryotic elongation factor 1A (eEF1A), preventing the delivery of aminoacyl-tRNAs to the ribosome during translation. This disruption ultimately leads to the inhibition of protein synthesis, affecting the growth and viability of cells. By targeting eEF1A, Chaetoglobosin F interferes with the elongation phase of protein synthesis, disrupting the normal cellular processes.
Chaetoglobosin F (CAS 55945-75-0) References
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- Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. | Cui, CM., et al. 2010. J Nat Prod. 73: 729-33. PMID: 20225834
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- Anti-HIV Compounds from the Deep-Sea-Derived Fungus Chaetomium globosum. | Hu, HQ., et al. 2022. Chem Biodivers. 19: e202100804. PMID: 34799976
- Concentration-dependent influence of various cytochalasins and chaetoglobosins on the phalloidin-induced polymerization of G-actin in 0.6 M potassium iodide. | Wieland, T. and Löw, I. 1980. Biochemistry. 19: 3363-7. PMID: 6893272
- The effects of cytochalasins on lymphocytes. Identification of distinct cytochalasin-binding sites in relation to mitogenic response and hexose transport. | Mookerjee, BK., et al. 1981. J Biol Chem. 256: 1290-300. PMID: 7451506
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chaetoglobosin F, 1 mg | sc-503080 | 1 mg | $240.00 |