Molecular structure of Chaetoglobosin A
Chaetoglobosin A (CAS 50335-03-0)
Alternate Names:
Chaetoglobosins
Application:
Chaetoglobosin A is a mycotoxic cytochalasan compound
CAS Number:
50335-03-0
Purity:
≥98%
Molecular Weight:
528.64
Molecular Formula:
C32H36N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Chaetoglobosin A is a mycotoxic cytochalasan compound found in fungi of the Chaetomium species. It acts through multiple pathways, including the inhibition of pro-inflammatory cytokines, the induction of apoptosis, and the inhibition of angiogenesis. Additionally, Chaetoglobosin A may act to inhibit the activity of certain enzymes, including cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). The compound has been found to have antibacterial, anti-inflammatory, antioxidant, and anti-cancer properties. In vitro studies have shown that Chaetoglobosin A can inhibit the growth of certain cancer cells, including human lung adenocarcinoma and colon cancer cells, and induce apoptosis in cell lines such as human breast cancer cells.
Chaetoglobosin A (CAS 50335-03-0) References
- Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognita. | Hu, Y., et al. 2013. J Agric Food Chem. 61: 41-6. PMID: 23214998
- Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis. | Ishiuchi, K., et al. 2013. J Am Chem Soc. 135: 7371-7. PMID: 23611317
- Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. | Knudsen, PB., et al. 2014. Leukemia. 28: 1289-98. PMID: 24280868
- New production process of the antifungal chaetoglobosin A using cornstalks. | Jiang, C., et al. 2017. Braz J Microbiol. 48: 410-418. PMID: 28223029
- Gα-cAMP/PKA pathway positively regulates pigmentation, chaetoglobosin A biosynthesis and sexual development in Chaetomium globosum. | Hu, Y., et al. 2018. PLoS One. 13: e0195553. PMID: 29652900
- Antimicrobial activities of endophytic fungi of the Sri Lankan aquatic plant Nymphaea nouchali and chaetoglobosin A and C, produced by the endophytic fungus Chaetomium globosum. | Dissanayake, RK., et al. 2016. Mycology. 7: 1-8. PMID: 30123610
- Effects of rice straw structure on chaetoglobosin A production by Chaetomium globosum CGMCC 6882. | Wang, Z., et al. 2020. Int J Biol Macromol. 150: 1223-1228. PMID: 31743701
- Functional analysis of a chaetoglobosin A biosynthetic regulator in Chaetomium globosum. | Cheng, M., et al. 2021. Fungal Biol. 125: 201-210. PMID: 33622536
- Deletion of a Rare Fungal PKS CgPKS11 Promotes Chaetoglobosin A Biosynthesis, Yet Defers the Growth and Development of Chaetomium globosum. | Xiang, B., et al. 2021. J Fungi (Basel). 7: PMID: 34575788
- New insight into the production improvement and resource generation of chaetoglobosin A in Chaetomium globosum. | Zhao, S., et al. 2022. Microb Biotechnol. 15: 2562-2577. PMID: 35930651
- CgVeA, a light signaling responsive regulator, is involved in regulation of chaetoglobosin A biosynthesis and conidia development in Chaetomium globosum. | Wang, Z., et al. 2022. Synth Syst Biotechnol. 7: 1084-1094. PMID: 35949485
- Chaetoglobosin A contributes to the antagonistic action of Chaetomium globosum strain 61239 toward the apple Valsa canker pathogen Cytospora mali. | Liang, X., et al. 2023. Phytopathology.. PMID: 37069143
- Acute toxic effects of chaetoglobosin A, a new cytochalasan compound produced by Chaetomium globosum, on mice and rats. | Ohtsubo, K., et al. 1978. Jpn J Exp Med. 48: 105-10. PMID: 713122
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chaetoglobosin A, 1 mg | sc-394292 | 1 mg | $177.00 | |||
Chaetoglobosin A, 1 mg | sc-394292-CW | 1 mg | $200.00 | |||
Chaetoglobosin A, 5 mg | sc-394292A | 5 mg | $533.00 | |||
Chaetoglobosin A, 10 mg | sc-394292B | 10 mg | $959.00 | |||
Chaetoglobosin A, 50 mg | sc-394292C | 50 mg | $3900.00 |