Molecular structure of Chaetocin, CAS Number: 28097-03-2
Chaetocin (CAS 28097-03-2)
See product citations (5)
Alternate Names:
Methyltransferase inhibitor
Application:
Chaetocin is a lysine-specific histone methyltransferase inhibitor
CAS Number:
28097-03-2
Purity:
≥98%
Molecular Weight:
696.84
Molecular Formula:
C30H28N6O6S4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Chaetocin is a mycotoxin originally found in Chaetomium species of fungi. Mechanistic studies show that chaetocin is taken up in the cells by a process that requires intact/unreduced disulfides for uptake. Once inside, this compound imposes oxidative stress and consequent apoptosis induction. Other studies have shown chaetocin to reduce lysine-specific histone methyltransferase effects of SUV39H, which play a key role in maintaining stable gene expression patterns during embryonic development and cellular differentiation. Additionally, this agent is reported to cause profound chromatin reorganization in fibroblast nuclei by inducing chromatin condensation/clustering. Consequentially, chaetocin impairs Trx (thioredoxin) systems, which are essential for deoxynucleotide synthesis and involved in a broad range of cellular functions. Chaetocin is an inhibitor of G9a, SUV39H1 and TrxR1.
Chaetocin (CAS 28097-03-2) References
- Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. | Greiner, D., et al. 2005. Nat Chem Biol. 1: 143-5. PMID: 16408017
- Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. | Isham, CR., et al. 2007. Blood. 109: 2579-88. PMID: 17090648
- Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin. | Illner, D., et al. 2010. Exp Cell Res. 316: 1662-80. PMID: 20302859
- Chaetocin inhibits RANKL-induced osteoclast differentiation through reduction of Blimp1 in Raw264.7 cells. | Zhao, N., et al. 2015. Life Sci. 143: 1-7. PMID: 26514304
- Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK. | Bae, JS., et al. 2016. Chem Biol Interact. 245: 66-71. PMID: 26748310
- The anticancer effect of chaetocin is enhanced by inhibition of autophagy. | Jung, HJ., et al. 2016. Cell Death Dis. 7: e2098. PMID: 26890137
- Chaetocin attenuates gout in mice through inhibiting HIF-1α and NLRP3 inflammasome-dependent IL-1β secretion in macrophages. | Mian Wu, ., et al. 2019. Arch Biochem Biophys. 670: 94-103. PMID: 31255694
- Identification of Chaetocin as a Potent non-ROS-mediated Anticancer Drug Candidate for Gastric Cancer. | Liao, X., et al. 2019. J Cancer. 10: 3678-3690. PMID: 31333785
- Chaetocin induces caspase-dependent apoptosis in ovarian cancer cells via the generation of reactive oxygen species. | Li, Z., et al. 2019. Oncol Lett. 18: 1915-1921. PMID: 31423261
- Chaetocin Improves Pig Cloning Efficiency by Enhancing Epigenetic Reprogramming and Autophagic Activity. | Jeong, PS., et al. 2020. Int J Mol Sci. 21: PMID: 32650566
- Chaetocin induced chromatin condensation: effect on DNA repair signaling and survival. | Sak, A., et al. 2021. Int J Radiat Biol. 97: 494-506. PMID: 33428851
- Chaetocin Promotes Osteogenic Differentiation via Modulating Wnt/Beta-Catenin Signaling in Mesenchymal Stem Cells. | Liang, Y., et al. 2021. Stem Cells Int. 2021: 8888416. PMID: 33628276
- Combined Chaetocin/Trichostatin A Treatment Improves the Epigenetic Modification and Developmental Competence of Porcine Somatic Cell Nuclear Transfer Embryos. | Jeong, PS., et al. 2021. Front Cell Dev Biol. 9: 709574. PMID: 34692674
- Chaetocin attenuates atherosclerosis progression and inhibits vascular smooth muscle cell phenotype switching. | Chen, MY., et al. 2022. J Cardiovasc Transl Res. 15: 1270-1282. PMID: 35428928
- Chaetocin disrupts the SUV39H1-HP1 interaction independent of SUV39H1 methyltransferase activity. | Han, L., et al. 2023. Biochem J. 480: 421-432. PMID: 36896918
Inhibitor of:
2310079F23Rik, 2810422O20Rik, 2810474O19Rik, 4832428D23Rik, Ada1, ANKRD60, Arp, B630005N14Rik, BAZ2B, BC067068, BCDIN3, BMAL1, C14orf131, C1orf156, CBX6, CDYL2, CEM15, Chr-B, CXorf34, Dnmt3a, DPRX, EG243302, EHM2, EHMT1, Elongin A2, Fibrillarin-like 1, FOXD4L4, FTZ-F1, Gγ 3, G9a, GATA-3, H3-K9-HMTase, hCG_1982709, HEMK2, Histone cluster 1 H1T, Histone cluster 1 H2AA4, Histone cluster 1 H3H, Histone cluster 1 H4F, Histone cluster 1 H4J, Histone cluster 2 H3B, Histone H2B, Histone H2B.S, Histone H3.3A, Histone H3F3C, HIV-1 Tat-SF1, HP1, HP1β, HP1γ, HP1BP3, Khdc1a, KMT5 (lysine methyltransferase), L3MBTL4, Lce1g, LHX8, LOC100040962, LOC100041177, LOC728957, Mael, MBD3L4, MCART1, Menin, Mesogenin 1, METT11D1, METTL12, METTL2, METTL23, METTL25, METTL2A, METTL2B, MGC50559_4833442J19Rik, MOX-2, MSL3L2, NSD2, NSUN1, NSUN5, NSUN5C, PA1, PCDHGB5, PCGF6, PHF13, PHF20, PHF20L1, PHF21B, PIWIL4, PRDM12, PRDM8, PSIP1, RAI15, RG9MTD1, RNMT, RNMTL1, SCML2, Set2, SET8, SETD2, SETD4, SFMBT2, SMCHD1, SMYD1, SMYD4, Sp5, SPP24, SPT4, ST7, SUV39H1, SUV39H2, SUV420H1, TBC1D24, TIGD4, TMEM108, TMEM145, Trimethyl Histone H4, TrxR1, Trypsin-10, TSPYL6, TSSC3, TXNL6, USF-1, ZBTB43, ZC3H13, ZFP39, ZFP40, ZFP433, ZFP59, ZFP61, ZFP712, ZFP719, ZKSCAN1, ZNF274, ZNF576, ZNF644, ZNF71, ZNF778, and ZNHIT1.Activator of:
ASH2L, ATAD2, BAF53B, BAZ1A, BRUNOL4, DAZAP1, DPPA4, E(z), EMID2, Histone cluster 1 H2AJ, Histone cluster 1 H2AM, Histone cluster 1 H2BL, Histone H2B.S, HIV gp24, HIV-1 Gag, HIV-1 Tat, Lamin A, MacroH2A1, Mel-18, Monomethyl Histone H4, MPc2, periphilin 1, PHF6, PRDM14, QKI, Set1B, SETD6, SLUG, STH1, SUV39H1, WIZ, ZNF408, ZNF579, ZNF709, and ZNF721.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chaetocin, 200 µg | sc-200893 | 200 µg | $126.00 |