CGS 35066 CAS: 261619-50-5
MF: C16H16NO6P
MW: 349.28
A potent endothelin-converting enzyme (ECE) inhibitor.

CGS 35066 (CAS 261619-50-5)

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Synonym: α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid
Application: A potent endothelin-converting enzyme (ECE) inhibitor
CAS Number: 261619-50-5
Purity: >98%
Molecular Weight: 349.28
Molecular Formula: C16H16NO6P
* Refer to Certificate of Analysis for lot specific data (including water content).
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CGS 35066 is a a potent endothelin-converting enzyme (ECE) inhibitor. When compared to neutral endopeptidase 24.11, it displays > 100-fold selectivity (IC50 values are 22 and 2300 nM respectively). Another interesting property of CGS 35066 is that it blocks the hypertensive effects induced by big ET-1 in vitro and is able to reduce the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).


References

1. De Lombaert, S., et al. 2000. J. Med. Chem. 43: 488-504. PMID: 10669576
2. Trapani, A.J., et al. 2000. J. Cardiovasc. Pharmacol. 36: S40-S43. PMID: 11078331
3. Kwan, A.L., et al. 2002. Neuroreport. 13: 197-199. PMID: 11893909

Physical State :
Solid
Solubility :
Soluble in 1eq. NaOH to 100 mM
Storage :
Desiccate at room temperature
Melting Point :
304.03° C (Predicted)
Boiling Point :
~638.89° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
neutral endopeptidase 24: IC50 = 22 nM; neutral endopeptidase 11: IC50 = 3300 nM; Endothelin-converting enzyme 1: IC50 = 22 nM (human); Neprilysin: IC50 = 2300 nM (human); Neprilysin: IC50 = 2300 nM (Rattus norvegicus)
pK Values :
pKa: 0.79, pKb: 10.58
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9863167
MDL Number :
MFCD09971085
SMILES :
C1=CC=C2C(=C1)C3=C(O2)C=C(C=C3)C[[email protected]@H](C(=O)O)NCP(=O)(O)O

Download SDS (MSDS)

Certificate of Analysis

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