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CGS 35066 is a a potent endothelin-converting enzyme (ECE) inhibitor. When compared to neutral endopeptidase 24.11, it displays > 100-fold selectivity (IC50 values are 22 and 2300 nM respectively). Another interesting property of CGS 35066 is that it blocks the hypertensive effects induced by big ET-1 in vitro and is able to reduce the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).
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