Molecular structure of CGP 7930, CAS Number: 57717-80-3
CGP 7930 (CAS 57717-80-3)
Alternate Names:
3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol
Application:
CGP 7930 is positive allosteric modulator of GABAB receptors
CAS Number:
57717-80-3
Molecular Weight:
292.46
Molecular Formula:
C19H32O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CGP 7930 is a positive allosteric modulator of GABAB receptors. CGP 7930 increases the potency and efficacy of GABA at both native and recombinant GABAB receptors (EC50 values are 5.37 and 4.60μM respectively) and enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons.
CGP 7930 (CAS 57717-80-3) References
- Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. | Urwyler, S., et al. 2001. Mol Pharmacol. 60: 963-71. PMID: 11641424
- The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats. | Liang, JH., et al. 2006. Neuropharmacology. 50: 632-9. PMID: 16406445
- Differential modulation by the GABAB receptor allosteric potentiator 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area. | Chen, Y., et al. 2006. J Pharmacol Exp Ther. 317: 1170-7. PMID: 16507713
- Effects of GABA(B) receptor agents on cocaine priming, discrete contextual cue and food induced relapses. | Filip, M. and Frankowska, M. 2007. Eur J Pharmacol. 571: 166-73. PMID: 17610868
- Effects of GABA(B) receptor antagonist, agonists and allosteric positive modulator on the cocaine-induced self-administration and drug discrimination. | Filip, M., et al. 2007. Eur J Pharmacol. 574: 148-57. PMID: 17698060
- Effects of GABAB receptor ligands in animal tests of depression and anxiety. | Frankowska, M., et al. 2007. Pharmacol Rep. 59: 645-55. PMID: 18195453
- Effects of imipramine or GABA(B) receptor ligands on the immobility, swimming and climbing in the forced swim test in rats following discontinuation of cocaine self-administration. | Frankowska, M., et al. 2010. Eur J Pharmacol. 627: 142-9. PMID: 19878670
- Anticonvulsant action of GABAB receptor positive modulator CGP7930 in immature rats. | Mareš, P. 2012. Epilepsy Res. 100: 49-54. PMID: 22341143
- Elucidation of a CGP7930 in vitro metabolite by liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry. | Wang, H., et al. 2016. Rapid Commun Mass Spectrom. 30: 491-6. PMID: 26777679
- The GABAB positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABAB receptors. | Olianas, MC., et al. 2017. Eur J Pharmacol. 794: 135-146. PMID: 27876620
Inhibitor of:
RNA pol σ 70.Activator of:
GABAB R1, and GABAB R2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CGP 7930, 10 mg | sc-203543 | 10 mg | $155.00 | |||
CGP 7930, 50 mg | sc-203543A | 50 mg | $625.00 |