Date published: 2026-4-12

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CGP 46381 (CAS 123691-14-5)

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Application:
CGP 46381 is a selective GABAB receptor antagonist
CAS Number:
123691-14-5
Molecular Weight:
219.26
Molecular Formula:
C10H22NO2P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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CGP 46381 is a compound extensively utilized in neurobiological research, particularly as a selective antagonist of the GABA B receptor subtypes. The chemical′s ability to bind to these receptor sites allows researchers to study the inhibitory neurotransmitter GABA′s role in various neurological processes. Consequently, CGP 46381 is instrumental in exploring the function of GABA B receptors in synaptic transmission, plasticity, and neuron excitability. In some studies, this chemical is applied to decipher the GABAergic system′s involvement in behavior and memory. Moreover, CGP 46381 is valuable in examining the mechanisms underlying the regulation of neurotransmitter release, providing insights into fundamental neurophysiological functions.


CGP 46381 (CAS 123691-14-5) References

  1. GABA(B) receptor inhibition causes locomotor stimulation in mice.  |  Colombo, G., et al. 2001. Eur J Pharmacol. 433: 101-4. PMID: 11755139
  2. Attenuation of morphine withdrawal signs by the GABA(B) receptor agonist baclofen.  |  Bexis, S., et al. 2001. Life Sci. 70: 395-401. PMID: 11798009
  3. Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid.  |  Carai, MA., et al. 2002. Eur J Pharmacol. 441: 157-63. PMID: 12063087
  4. GABA(B) receptor agonists reverse akinesia following intranigral or intracerebroventricular injection in the reserpine-treated rat.  |  Johnston, T. and Duty, S. 2003. Br J Pharmacol. 139: 1480-6. PMID: 12922935
  5. GABAB-receptor-mediated suppression of sympathetic outflow from the spinal cord of neonatal rats.  |  Cheng, YW., et al. 2005. J Appl Physiol (1985). 99: 1658-67. PMID: 16037405
  6. Increased GABA(B) receptor-mediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures.  |  Pacey, LK., et al. 2009. Mol Pharmacol. 76: 18-24. PMID: 19351745
  7. Gamma-Aminobutyric Acid (GABA) Promotes Growth in Zebrafish Larvae by Inducing IGF-1 Expression via GABAA and GABAB Receptors.  |  Athapaththu, AMGK., et al. 2021. Int J Mol Sci. 22: PMID: 34681914
  8. Plasticity of GABAB receptor in rat spinal cord detected by autoradiography.  |  Malcangio, M., et al. 1993. Eur J Pharmacol. 250: 153-6. PMID: 8119313
  9. The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro.  |  Olpe, HR., et al. 1993. Eur J Pharmacol. 233: 179-86. PMID: 8385620
  10. Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade.  |  Brucato, FH., et al. 1996. Neuroscience. 74: 331-9. PMID: 8865186
  11. Pharmacological profiles of absence seizure-induced increases in CRE- and AP-1 DNA-binding activities in gamma-butyrolactone-treated mice.  |  Ishige, K., et al. 1998. Nihon Shinkei Seishin Yakurigaku Zasshi. 18: 117-22. PMID: 9866826

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

CGP 46381, 10 mg

sc-361140
10 mg
$179.00

CGP 46381, 50 mg

sc-361140A
50 mg
$754.00