CGP 12177 hydrochloride CAS: 81047-99-6
MF: C14H22ClN3O3
MW: 315.8
A β1/β2-AR adrenoreceptor agonist.

CGP 12177 hydrochloride (CAS 81047-99-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 148ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one hydrochloride
Application: A β1/β2-AR adrenoreceptor agonist
CAS Number: 81047-99-6
Molecular Weight: 315.8
Molecular Formula: C14H22ClN3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

CGP 12177 hydrochloride is a β1-AR and β2-AR adrenoreceptor antagonist. Also behaves non-conventionally as a β3-AR partial agonist.


Staehelin et al (1983) CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells. J.Biol.Chem. 258 3496. Strosberg and Pietri-Rouxel (1996) Function and regulation of the b3-adrenoceptor. TiPS 17 373. Galitzky et al (1998) On the presence of a putative fourth b-adrenoceptor in human adipose tissue. TiPS 19 164. Preitner et al (1998) Metabolic response to various b-adrenoceptor agonists in b3-adrenoceptor knockout mice: evidence for a new b-adrenergic receptor in brown adipose tissue. Br.J.Pharmacol. 124 1684.

Physical State :
Solubility :
Soluble in water (50 mM), and DMSO (>10 mg/ml).
Storage :
Store at room temperature
Melting Point :
258-260° C
Refractive Index :
n20D ~1.55 (Predicted)
IC50 :
β3-AR: EC5050 = 2 µM (human)
Ki Data :
β1-AR: Ki= 0.9 nM; β2-AR : Ki= 4 nM; β3-AR: Ki= 88 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 114ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 100ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.