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CGP 12177 hydrochloride is a β1-AR and β2-AR adrenoreceptor antagonist. Also behaves non-conventionally as a β3-AR partial agonist.
Staehelin et al (1983) CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells. J.Biol.Chem. 258 3496. Strosberg and Pietri-Rouxel (1996) Function and regulation of the b3-adrenoceptor. TiPS 17 373. Galitzky et al (1998) On the presence of a putative fourth b-adrenoceptor in human adipose tissue. TiPS 19 164. Preitner et al (1998) Metabolic response to various b-adrenoceptor agonists in b3-adrenoceptor knockout mice: evidence for a new b-adrenergic receptor in brown adipose tissue. Br.J.Pharmacol. 124 1684.
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