cGKIα inhibitor-Cell Permeable DT-3
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Application:
cGKIα inhibitor-Cell Permeable DT-3 is a highly potent membrane-permeable Drosophila Antennapedia homeodomain fused peptide that selectively inhibits PKG
Purity:
≥97%
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
cGKIα Inhibitor-Cell Permeable DT-3 is a highly potent membrane-permeable Drosophila Antennapedia homeodomain fused peptide that selectively inhibits PKG. It also inhibits PKA at much higher concentrations. Also reactive with additional species, including cow and pig.
cGKIα inhibitor-Cell Permeable DT-3 References
- Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation. | Dostmann, WR., et al. 2000. Proc Natl Acad Sci U S A. 97: 14772-7. PMID: 11121077
- Inhibition of cGMP-dependent protein kinase by the cell-permeable peptide DT-2 reveals a novel mechanism of vasoregulation. | Taylor, MS., et al. 2004. Mol Pharmacol. 65: 1111-9. PMID: 15102939
- cGMP-dependent kinase regulates response sensitivity of the mouse on bipolar cell. | Snellman, J. and Nawy, S. 2004. J Neurosci. 24: 6621-8. PMID: 15269274
- Progesterone regulates granulosa cell viability through a protein kinase G-dependent mechanism that may involve 14-3-3sigma. | Peluso, JJ. and Pappalardo, A. 2004. Biol Reprod. 71: 1870-8. PMID: 15286034
- cGMP-dependent protein kinases in drug discovery. | Schlossmann, J. and Hofmann, F. 2005. Drug Discov Today. 10: 627-34. PMID: 15894227
- Nitric oxide and cGMP protein kinase (cGK) regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19. | Giordano, D., et al. 2006. Blood. 107: 1537-45. PMID: 16249377
- Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G. | Kwan, HY., et al. 2006. J Cell Physiol. 207: 315-21. PMID: 16331690
- The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway. | Pyriochou, A., et al. 2007. J Cell Physiol. 211: 197-204. PMID: 17226792
- Progesterone maintains basal intracellular adenosine triphosphate levels and viability of spontaneously immortalized granulosa cells by promoting an interaction between 14-3-3sigma and ATP synthase beta/precursor through a protein kinase G-dependent mechanism. | Peluso, JJ., et al. 2007. Endocrinology. 148: 2037-44. PMID: 17303654
- Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase. | Zhou, W., et al. 2007. Am J Physiol Lung Cell Mol Physiol. 292: L1459-66. PMID: 17322285
- ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIalpha. | Stratton, RC., et al. 2008. Biochem Biophys Res Commun. 368: 965-70. PMID: 18280805
- Nitric oxide-dependent human acrosomal loss induced by PPCM (SAMMA) and by nitric oxide donors occurs by independent pathways: basis for synthesis of an improved contraceptive microbicide. | Anderson, RA., et al. 2009. J Androl. 30: 168-82. PMID: 18974424
- Role of cGMP-dependent protein kinase in regulation of pulmonary vascular smooth muscle cell adhesion and migration: effect of hypoxia. | Negash, S., et al. 2009. Am J Physiol Heart Circ Physiol. 297: H304-12. PMID: 19411288
- 17Beta-estradiol elevates cGMP and, via plasma membrane recruitment of protein kinase GIalpha, stimulates Ca2+ efflux from rat hepatocytes. | Stratton, RC., et al. 2010. J Biol Chem. 285: 27201-27212. PMID: 20566641
- Essential roles of the nitric oxide (no)/cGMP/protein kinase G type-Iα (PKG-Iα) signaling pathway and the atrial natriuretic peptide (ANP)/cGMP/PKG-Iα autocrine loop in promoting proliferation and cell survival of OP9 bone marrow stromal cells. | Wong, JC. and Fiscus, RR. 2011. J Cell Biochem. 112: 829-39. PMID: 21328456
Inhibitor of:
PKA, and Ser/Thr Protein Kinase.Activator of:
cGKI α.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cGKIα inhibitor-Cell Permeable DT-3, 1 mg | sc-3101 | 1 mg | $95.00 |