Molecular structure of CGH 2466, CAS Number: 1177618-54-0
CGH 2466 (CAS 1177618-54-0)
Alternate Names:
4-(3,4-Dichlorophenyl)-5-(4-pyridin yl)-2-thiazolamine dihydrochloride
Application:
CGH 2466 is an Adenosine A1-R, Adenosine A2B-R, Adenosine A3-R, and p38 inhibitor
CAS Number:
1177618-54-0
Purity:
≥99%
Molecular Weight:
395.13
Molecular Formula:
C14H9N3SCl2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
CGH 2466 functions as a potent inhibitor of a specific enzyme involved in cellular signaling pathways. It exerts its mechanism of action by binding to the active site of the enzyme, thereby preventing its normal function and disrupting downstream signaling cascades. This disruption ultimately leads to the inhibition of cell proliferation and survival. CGH 2466 may modulate the expression of certain genes involved in cell cycle regulation, further contributing to its inhibitory effects on cellular growth. Its mechanism of action at the molecular level involves interfering with the phosphorylation of key proteins involved in cell signaling, ultimately leading to the suppression of cell growth and proliferation.
CGH 2466 (CAS 1177618-54-0) References
- CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities. | Trifilieff, A., et al. 2005. Br J Pharmacol. 144: 1002-10. PMID: 15685201
- Drugs in clinical development for chronic obstructive pulmonary disease. | Molfino, NA. 2005. Respiration. 72: 105-12. PMID: 15753645
- Chronic obstructive pulmonary disease: histopathology, inflammation and potential therapies. | Molfino, NA. and Jeffery, PK. 2007. Pulm Pharmacol Ther. 20: 462-72. PMID: 16798034
- Recent progress in the development of adenosine receptor ligands as antiinflammatory drugs. | Akkari, R., et al. 2006. Curr Top Med Chem. 6: 1375-99. PMID: 16918456
- Mitogen-activated protein kinases as therapeutic targets for asthma. | Khorasanizadeh, M., et al. 2017. Pharmacol Ther. 174: 112-126. PMID: 28223227
Inhibitor of:
Adenosine A1-R, Adenosine A2B-R, Adenosine A3-R, p38, PDE4D, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CGH 2466, 10 mg | sc-203541 | 10 mg | $132.00 | |||
CGH 2466, 50 mg | sc-203541A | 50 mg | $559.00 |