Molecular structure of CFTR Inhibitor-172, CAS Number: 307510-92-5
CFTR Inhibitor-172 (CAS 307510-92-5)
See product citations (10)
Alternate Names:
3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone; 4-[4-Oxo-2-thioxo-3-(3-trifluoromethyl-phenyl)-thiazolidin-5-ylidenemethyl]-benzoic acid;
Application:
CFTR Inhibitor-172 is a voltage-independent inhibitor of CFTR
CAS Number:
307510-92-5
Purity:
≥95%
Molecular Weight:
409.40
Molecular Formula:
C18H10F3NO3S2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CFTR Inhibitor-172 is a voltage-independent inhibitor of CFTR chloride channel blocker (Ki = 300 nM). It shows no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. CFTR Inhibitor-172 is also shown to block intestinal fluid secretion that is cholera toxin-induced.
CFTR Inhibitor-172 (CAS 307510-92-5) References
- The Role of Short-Chain Fatty Acids, Produced by Anaerobic Bacteria, in the Cystic Fibrosis Airway. | Mirković, B., et al. 2015. Am J Respir Crit Care Med. 192: 1314-24. PMID: 26266556
- Nobiletin Stimulates Chloride Secretion in Human Bronchial Epithelia via a cAMP/PKA-Dependent Pathway. | Hao, Y., et al. 2015. Cell Physiol Biochem. 37: 306-20. PMID: 26316078
- Mutations of Cystic Fibrosis Transmembrane Conductance Regulator Gene Cause a Monocyte-Selective Adhesion Deficiency. | Sorio, C., et al. 2016. Am J Respir Crit Care Med. 193: 1123-33. PMID: 26694899
- [Impact of the CFTR chloride channel on the cytoskeleton of mouse Sertoli cells]. | Zhang, HL., et al. 2016. Zhonghua Nan Ke Xue. 22: 110-5. PMID: 26939393
- Anoctamin 6 Contributes to Cl- Secretion in Accessory Cholera Enterotoxin (Ace)-stimulated Diarrhea: AN ESSENTIAL ROLE FOR PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIP2) SIGNALING IN CHOLERA. | Aoun, J., et al. 2016. J Biol Chem. 291: 26816-26836. PMID: 27799301
- MDCK cells are capable of water secretion and reabsorption in response to changes in the ionic environment. | Capra, JP. and Eskelinen, SM. 2017. Can J Physiol Pharmacol. 95: 72-83. PMID: 27901358
- Lower Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Promotes the Proliferation and Migration of Endometrial Carcinoma. | Xia, X., et al. 2017. Med Sci Monit. 23: 966-974. PMID: 28225751
- CFTR modulates RPS27 gene expression using chloride anion as signaling effector. | Valdivieso, ÁG., et al. 2017. Arch Biochem Biophys. 633: 103-109. PMID: 28941802
- Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease. | Terryah, ST., et al. 2018. Am J Physiol Lung Cell Mol Physiol. 314: L192-L205. PMID: 28982737
- Resveratrol dimer trans-ε-viniferin prevents rotaviral diarrhea in mice by inhibition of the intestinal calcium-activated chloride channel. | Yu, B., et al. 2018. Pharmacol Res. 129: 453-461. PMID: 29155014
- Naringenin Regulates CFTR Activation and Expression in Airway Epithelial Cells. | Shi, R., et al. 2017. Cell Physiol Biochem. 44: 1146-1160. PMID: 29179179
- The bile acids, deoxycholic acid and ursodeoxycholic acid, regulate colonic epithelial wound healing. | Mroz, MS., et al. 2018. Am J Physiol Gastrointest Liver Physiol. 314: G378-G387. PMID: 29351391
- Cigarette Smoke Exposure Inhibits Bacterial Killing via TFEB-Mediated Autophagy Impairment and Resulting Phagocytosis Defect. | Pehote, G., et al. 2017. Mediators Inflamm. 2017: 3028082. PMID: 29445254
- β- Adrenoceptors activate hepatic glutathione efflux through an unreported pathway. | Matuz-Mares, D., et al. 2018. Arch Biochem Biophys. 644: 47-56. PMID: 29496543
Inhibitor of:
AI747448, Bestrophin (BEST), Bestrophin-2, CFTR, CLC-2, CLCA5_Clac5, CLCN5 (CLC-5), KCC2, NALP1B, NIPSNAP1, SLC26A11, SLC26A3, SLC26A7, SLC26A8, and SLC26A9.Activator of:
KCNH1, LNX4, and SLC26A8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CFTR Inhibitor-172, 10 mg | sc-204680 | 10 mg | $168.00 | |||
CFTR Inhibitor-172, 50 mg | sc-204680A | 50 mg | $520.00 |