cFMS Receptor Inhibitor III CAS: 959861-21-3
MF: C25H23N3O3S
MW: 445.53
A cell-permeable anilinoquinoline compound.

cFMS Receptor Inhibitor III (CAS 959861-21-3)

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Alternate Names: 4-(3,4-Dimethylanilino)-7-(4-(methylsulfonyl)phenyl)quinoline-3-carboxamide; CSF-1 Receptor Inhibitor III
Application: cFMS Receptor Inhibitor III is a cell-permeable anilinoquinoline compound
CAS Number: 959861-21-3
Molecular Weight: 445.53
Molecular Formula: C25H23N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

cFMS Receptor Inhibitor III is a cell-permeable anilinoquinoline compound that acts as a strong, active site-targeting inhibitor of M-CSF/c-Fms-CSF-1R (MCSF receptor/cFMS). cFMS Receptor Inhibitor III is 100-fold more potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells than the cFMS-independent growth of NSO cells.


References

1. Smalley, Terrence L., et al., 2007. Synthesis of novel anilinoquinolines as c-fms inhibitors. Bioorganic & medicinal chemistry letters. 17(22): 6257-60. PMID: 17870531

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml).
Storage :
Store at 4° C
Boiling Point :
699.13° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
MCSF receptor/cFMS : IC50 = 8 nM; cFMS-dependent growth of M-NSF-60 cells : IC50 = 0.1 µM; cFMS-independent growth of NSO cells : IC50 = 10 µM
pK Values :
pKb: 4.73 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25021199
SMILES :
CC1=C(C=C(C=C1)NC2=C3C=CC(=CC3=NC=C2C(=O)N)C4=CC=C(C=C4)S(=O)(=O)C)C

Download SDS (MSDS)

Certificate of Analysis

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Will this compound work/has it been tested both in vivo (mice) and in vitro?

Asked by: PMT0
Thank you for your question. Please contact our Technical Service Department for current information about any application testing for this chemical.
Answered by: Technical Support
Date published: 2018-12-12
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