cFMS Receptor Inhibitor III is a cell-permeable anilinoquinoline compound that acts as a strong, active site-targeting inhibitor of M-CSF/c-Fms-CSF-1R (MCSF receptor/cFMS). cFMS Receptor Inhibitor III is 100-fold more potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells than the cFMS-independent growth of NSO cells.
1. Smalley, Terrence L., et al., 2007. Synthesis of novel anilinoquinolines as c-fms inhibitors. Bioorganic & medicinal chemistry letters. 17(22): 6257-60. PMID: 17870531
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