Molecular structure of CFM-2, CAS Number: 178616-26-7
CFM-2 (CAS 178616-26-7)
Application:
CFM-2 is a non-competitive antagonist of the AMPA receptors
CAS Number:
178616-26-7
Molecular Weight:
311.3
Molecular Formula:
C17H17N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CFM-2 is a novel, selective, non-competitive AMPA antagonist1.
CFM-2 (CAS 178616-26-7) References
- Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. | De Sarro, G., et al. 1999. Eur J Pharmacol. 368: 149-59. PMID: 10193651
- Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats. | De Sarro, G., et al. 1999. Pharmacol Biochem Behav. 63: 621-7. PMID: 10462191
- Determination of new 2,3-benzodiazepines in rat plasma using high-performance liquid chromatography with ultraviolet detection. | Rizzo, M., et al. 1999. J Chromatogr B Biomed Sci Appl. 731: 207-15. PMID: 10510773
- Glutamate receptors on human melanocytes regulate the expression of MiTF. | Hoogduijn, MJ., et al. 2006. Pigment Cell Res. 19: 58-67. PMID: 16420247
- An alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate glutamate-receptor antagonist can inhibit premicturition contractions in rats with bladder outlet obstruction. | Kitta, T., et al. 2007. BJU Int. 100: 181-6. PMID: 17488306
- AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth. | Stepulak, A., et al. 2007. Cancer Biol Ther. 6: 1908-15. PMID: 18059166
- Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. | Park, JS., et al. 2008. Mol Pain. 4: 67. PMID: 19116032
- AMPA Receptor Antagonist CFM-2 Decreases Survivin Expression in Cancer Cells. | Ruiz, DS., et al. 2018. Anticancer Agents Med Chem. 18: 591-596. PMID: 29493464
- GluR2 can Drive Neuroinflammation and Cognitive Impairments Following Peripherally Repeated Lipopolysaccharide Exposures. | He, X., et al. 2024. Neurochem Res.. PMID: 38837093
- 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. | Chimirri, A., et al. 1997. J Med Chem. 40: 1258-69. PMID: 9111300
Inhibitor of:
GluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CFM-2, 10 mg | sc-203429 | 10 mg | $207.00 |