CFM-2 CAS: 178616-26-7
MF: C17H17N3O3
MW: 311.3
A non-competitive antagonist of the AMPA receptors.

CFM-2 (CAS 178616-26-7)

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Application: A non-competitive antagonist of the AMPA receptors
CAS Number: 178616-26-7
Molecular Weight: 311.3
Molecular Formula: C17H17N3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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CFM-2 is a novel, selective, non-competitive GluR (AMPA) antagonist.


References

1. Chimirri, A., et al. 1997. J. Med. Chem. 40: 1258-1269. PMID: 9111300
2. De Sarro, G., et al. 1999. Eur. J. Pharmacol. 368: 149-159. PMID: 10193651
3. De Sarro, G., et al. 1999. Pharmacol. Biochem. Behav. 63: 621-627. PMID: 10462191

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
225-227° C
Density :
1.32 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
AMPA activated current in xenopus oocytes expressing rat cerebral cortex poly(A)+ RNA.: IC50 = 180 µM (Rattus norvegicus)
pK Values :
pKa: 12.53 (Predicted), pKb: 3.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4377504
SMILES :
COC1=C(C=C2C(=C1)CC(=O)NN=C2C3=CC=C(C=C3)N)OC

Download SDS (MSDS)

Certificate of Analysis

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