Molecular structure of Cetirizine Methyl Ester, CAS Number: 83881-46-3
Cetirizine Methyl Ester (CAS 83881-46-3)
Application:
Cetirizine Methyl Ester is a 2nd generation H1 receptor antagonist
CAS Number:
83881-46-3
Molecular Weight:
402.91
Molecular Formula:
C22H27ClN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Cetirizine Methyl Ester is a modified oxidative metabolite of hydroxazine second generation histamine H1 receptor antagonist. As a second generation anti-histamine it binds with greater strength to the H1 receptor than the first generation and has been documented to have reduced brain penetration along with decreased binding to dopamine, serotonin, α-adrenergic, and calcium channel receptors.
Cetirizine Methyl Ester (CAS 83881-46-3) References
- Antiallergic effects of H1-receptor antagonists. | Baroody, FM. and Naclerio, RM. 2000. Allergy. 55 Suppl 64: 17-27. PMID: 11291777
- Binding characteristics of cetirizine and levocetirizine to human H(1) histamine receptors: contribution of Lys(191) and Thr(194). | Gillard, M., et al. 2002. Mol Pharmacol. 61: 391-9. PMID: 11809864
- Triprotic acid-base microequilibria and pharmacokinetic sequelae of cetirizine. | Marosi, A., et al. 2009. Eur J Pharm Sci. 37: 321-8. PMID: 19491022
- Screening of the most relevant parameters for method development in ultra-high performance hydrophilic interaction chromatography. | Periat, A., et al. 2013. J Chromatogr A. 1282: 72-83. PMID: 23411147
- Collision-induced dissociation pathways of H1-antihistamines by electrospray ionization quadrupole time-of-flight mass spectrometry. | Do, JA., et al. 2017. Arch Pharm Res. 40: 736-745. PMID: 28601982
- Risk assessment report of potential impurities in cetirizine dihydrochloride. | Leistner, A., et al. 2020. J Pharm Biomed Anal. 189: 113425. PMID: 32599488
- Photochemically Enabled, Ni-Catalyzed Cyanation of Aryl Halides. | Yan, Y., et al. 2022. Org Lett. 24: 2271-2275. PMID: 35316067
- Drug repurposing by in silico prediction of cyclizine derivatives as antihyperlipemic agents. | Afanamol, MS., et al. 2023. In Silico Pharmacol. 11: 27. PMID: 37899967
- A large-scale synthesis of enantiomerically pure cetirizine dihydrochloride using preparative chiral HPLC | Pflum D A, Wilkinson H S, Tanoury G J, et al. 2001. Organic Process Research & Development. 5: 110-115.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cetirizine Methyl Ester, 5 mg | sc-211058 | 5 mg | $300.00 |