Molecular structure of Cetirizine Dihydrochloride, CAS Number: 83881-52-1
Cetirizine Dihydrochloride (CAS 83881-52-1)
Alternate Names:
[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
Application:
Cetirizine Dihydrochloride is a Histamine H1 receptor inverse agonist
CAS Number:
83881-52-1
Purity:
≥99%
Molecular Weight:
461.81
Molecular Formula:
C21H25ClN2O3•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cetirizine Dihydrochloride is a compound extensively utilized in biochemistry research due to its properties as an antihistamine. In studies, it is employed to investigate the blockade of the H1 receptor, which plays a role in the body′s allergic response. Researchers are interested in the compound′s ability to modulate the effects of histamine, a key mediator in allergic reactions, and use it to study the pathways involved in histamine release and action. Furthermore, it is applied in the study of the kinetics and metabolism of antihistamines within biological systems. Furthermore, the compound is used in models to study the effects of histamine receptor blockade on physiological and behavioral responses.
Cetirizine Dihydrochloride (CAS 83881-52-1) References
- Stability of cetirizine dihydrochloride in solid state. | Zajac, M., et al. 2001. Acta Pol Pharm. 58: 21-3. PMID: 11370282
- Cetirizine dihydrochloride interaction with some diclofenac complexes. | Kenawi, IM., et al. 2005. Eur J Pharm Sci. 26: 341-8. PMID: 16137871
- Effects of cetirizine on human eosinophil and neutrophil activation in vitro. | Walsh, GM., et al. 1991. Int Arch Allergy Appl Immunol. 95: 158-62. PMID: 1682275
- Effects of cetirizine on isolated rat's tracheal smooth muscle. | Kao, CH., et al. 2009. Eur Arch Otorhinolaryngol. 266: 753-7. PMID: 18941763
- Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria. | Sugiura, K., et al. 2008. Nagoya J Med Sci. 70: 97-106. PMID: 18954028
- Cetirizine: actions on neurotransmitter receptors. | Snowman, AM. and Snyder, SH. 1990. J Allergy Clin Immunol. 86: 1025-8. PMID: 1979798
- Cetirizine dihydrochloride loaded microparticles design using ionotropic cross-linked chitosan nanoparticles by spray-drying method. | Li, FQ., et al. 2010. Arch Pharm Res. 33: 1967-73. PMID: 21191762
- Determination of stress-induced degradation products of cetirizine dihydrochloride by a stability-indicating RP-HPLC method. | Flórez Borges, P., et al. 2014. Daru. 22: 82. PMID: 25487685
- Ultrasound assisted enzyme catalyzed degradation of Cetirizine dihydrochloride. | Sutar, RS. and Rathod, VK. 2015. Ultrason Sonochem. 24: 80-6. PMID: 25515235
- Taste-masking assessment of orally disintegrating tablets and lyophilisates with cetirizine dihydrochloride microparticles. | Amelian, A., et al. 2017. Saudi Pharm J. 25: 1144-1150. PMID: 30166902
- Risk assessment report of potential impurities in cetirizine dihydrochloride. | Leistner, A., et al. 2020. J Pharm Biomed Anal. 189: 113425. PMID: 32599488
- Flow injection-chemiluminescence determination of cetirizine dihydrochloride in pharmaceuticals using tris(2,2'-bipyridyl)ruthenium (II)-Ag(III) complex reaction. | Moazzam, M., et al. 2021. Luminescence. 36: 674-683. PMID: 33179404
- Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride. | Pamlényi, K., et al. 2021. Pharmaceutics. 13: PMID: 33925927
Inhibitor of:
Histamine H1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cetirizine Dihydrochloride, 50 mg | sc-202992 | 50 mg | $122.00 |