Cetirizine Dihydrochloride CAS: 83881-52-1
MF: C21H25ClN2O3 2HCl
MW: 461.81
A Histamine H1 receptor inverse agonist.

Cetirizine Dihydrochloride (CAS 83881-52-1)

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Synonym: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
Application: A Histamine H1 receptor inverse agonist
CAS Number: 83881-52-1
Purity: ≥99%
Molecular Weight: 461.81
Molecular Formula: C21H25ClN2O3 2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cetirizine Dihydrochloride is a carboxylated metabolite of hydroxyzine that acts as a racemic selective Histamine H1 receptor inverse agonist. Compared to its parent compound, it shows similar antihistaminic activity, but with greater H1 selectivity and less sedative effects.


1. Snowman, A.M. , et al. 1990. J. Allergy Clin. Immunol. 86: 1025-1028. PMID: 1979798
2. Walsh, G.M., et al. 1991. Int. Arch. Allergy Appl. Immunol. 95: 158-162. PMID: 1682275
3. Sugiura, K., et al. 2008. Nagoya J Med Sci. 70: 97-106. PMID: 18954028
4. Kao, C.H., et al. 2009. Eur Arch Otorhinolaryngol. 266: 753-757. PMID: 18941763

Physical State :
Solubility :
Soluble in water (100 mM), DMSO (100 mM), ethanol (10 mM), and methanol.
Storage :
Store at room temperature
Melting Point :
225° C (dec.)
Boiling Point :
542.1° C at 760 (Predicted)
Refractive Index :
n20D ~1.59 (Predicted)
IC50 :
Cavia porcellus: IC50 = 0.38 µM; HERG: IC50 > 30 µM (human); Oryctolagus cuniculus: IC50 > 100 µM
Ki Data :
Histamine H1 Receptor: Ki= 5.89 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 2022
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

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