Cetirizine Dihydrochloride CAS: 83881-52-1
MF: C21H25ClN2O3 2HCl
MW: 461.81
A Histamine H1 receptor inverse agonist.

Cetirizine Dihydrochloride (CAS 83881-52-1)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 165ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
Application: A Histamine H1 receptor inverse agonist
CAS Number: 83881-52-1
Purity: ≥99%
Molecular Weight: 461.81
Molecular Formula: C21H25ClN2O3 2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Cetirizine Dihydrochloride is a carboxylated metabolite of hydroxyzine that acts as a racemic selective Histamine H1 receptor inverse agonist. Compared to its parent compound, it shows similar antihistaminic activity, but with greater H1 selectivity and less sedative effects.


References

1. Snowman, A.M. , et al. 1990. J. Allergy Clin. Immunol. 86: 1025-1028. PMID: 1979798
2. Walsh, G.M., et al. 1991. Int. Arch. Allergy Appl. Immunol. 95: 158-162. PMID: 1682275
3. Sugiura, K., et al. 2008. Nagoya J Med Sci. 70: 97-106. PMID: 18954028
4. Kao, C.H., et al. 2009. Eur Arch Otorhinolaryngol. 266: 753-757. PMID: 18941763

Physical State :
Solid
Solubility :
Soluble in water (100 mM), DMSO (100 mM), ethanol (10 mM), and methanol.
Storage :
Store at room temperature
Melting Point :
225° C (dec.)
Boiling Point :
542.1° C at 760 (Predicted)
Refractive Index :
n20D ~1.59 (Predicted)
IC50 :
Cavia porcellus: IC50 = 0.38 µM; HERG: IC50 > 30 µM (human); Oryctolagus cuniculus: IC50 > 100 µM
Ki Data :
Histamine H1 Receptor: Ki= 5.89 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AG0980000
PubChem CID :
55182
Merck Index :
14: 2022
MDL Number :
MFCD00941428
SMILES :
C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 150ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 13ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.