Cerebellin (CAS 94071-26-8)

Cerebellin, a neuropeptide comprising 16 amino acids, was first isolated from the cerebellum and functions as a crucial mediator in synaptic modulation and neuronal communication. This peptide, derived from a larger precursor protein, precerebellin, exerts its effects by binding to specific glutamate receptors, enhancing neurotransmitter release and synaptic transmission, which are fundamental for neuronal plasticity and connectivity. Research has leveraged cerebellin extensively to explore its role in neurodevelopment, particularly how it influences synaptic assembly and the functionality of glutamatergic synapses. Through studies primarily conducted in animal models, cerebellin has been shown to regulate calcium channels critical for neurotransmitter release, thus modulating neuronal excitability and interactions. These investigations provide valuable insights into the molecular mechanisms governing synaptic organization and plasticity, contributing to a broader understanding of learning processes and the potential developmental trajectories of neurobiological disorders. By focusing on the non-therapeutic aspects of cerebellin, researchers continue to uncover its significance in the complex network of neurodevelopment and synaptic functionality, highlighting its importance in the foundational study of neurobiology.