Cephradine (CAS 38821-53-3)
QUICK LINKS
Cephradine is a first-generation cephalosporin antibiotic that functions by inhibiting the synthesis of the bacterial cell wall. This interference ultimately leads to the disruption of the bacterial cell wall, causing cell lysis and death. Cephradine′s mechanism of action involves targeting the transpeptidase enzyme, which is responsible for forming the cross-links between peptidoglycan chains. By inhibiting this enzyme, cephradine disrupts the structural integrity of the bacterial cell wall, rendering the bacteria vulnerable to osmotic pressure and eventual cell lysis. This mechanism of action makes cephradine effective against a wide range of Gram-positive and some Gram-negative bacteria, making it useful for studying bacterial cell wall synthesis and potential targets for antibiotic development.
Cephradine (CAS 38821-53-3) References
- Crystal form of cephradine. | Sohn, YT. and Park, SH. 2006. Arch Pharm Res. 29: 178-82. PMID: 16526284
- Colorimetric detection of cephradine in pharmaceutical formulations via fluorosurfactant-capped gold nanoparticles. | Lu, C., et al. 2010. Talanta. 81: 698-702. PMID: 20188984
- Cephradine in pediatric practice. | Alban, J. 1976. Can Med Assoc J. 114: 192. PMID: 20312711
- Cephradine (Velosef) penetration of mandibular bone. | Middlehurst, RJ. and Rood, JP. 1990. Int J Oral Maxillofac Surg. 19: 120-1. PMID: 2111359
- Cephradine penetration of mandibular bone. | Middlehurst, RJ., et al. 1989. J Oral Maxillofac Surg. 47: 672-3. PMID: 2732825
- Controlled release of cephradine by biopolymers based target specific crosslinked hydrogels. | Butt, A., et al. 2019. Int J Biol Macromol. 121: 104-112. PMID: 30291928
- Colorimetric sensing of cephradine through polypropylene glycol functionalized gold nanoparticles. | Raja, DA., et al. 2021. R Soc Open Sci. 8: 210185. PMID: 34084550
- Cefadroxil. A review of its antibacterial, pharmacokinetic and therapeutic properties in comparison with cephalexin and cephradine. | Tanrisever, B. and Santella, PJ. 1986. Drugs. 32 Suppl 3: 1-16. PMID: 3542485
- Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens. | Khan, A., et al. 2022. Artif Cells Nanomed Biotechnol. 50: 312-321. PMID: 36380462
- Graphene oxide reinforced biopolymeric (chitosan) hydrogels for controlled cephradine release. | Qureshi, MAUR., et al. 2023. Int J Biol Macromol. 242: 124948. PMID: 37224895
- Cephradine-associated immune neutropenia. | Lawson, AA., et al. 1985. N Engl J Med. 312: 651. PMID: 3974638
- The transfer of cephradine across the placenta. | Lange, IR., et al. 1984. Br J Obstet Gynaecol. 91: 551-4. PMID: 6733058
- Cephradine penetration into cerebrospinal fluid and effects of its administration into the cerebral ventricles of cats. | Harik, SI., et al. 1977. Antimicrob Agents Chemother. 11: 909-11. PMID: 879742
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cephradine, 500 mg | sc-234296 | 500 mg | $130.00 |