Molecular structure of Cephalothin sodium salt, CAS Number: 58-71-9
Cephalothin sodium salt (CAS 58-71-9)
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Alternate Names:
7-(2-Thienylacetamido)cephalosporanic acid sodium salt
Application:
Cephalothin sodium salt is a firrst generation cephem antibiotic
CAS Number:
58-71-9
Molecular Weight:
418.41
Molecular Formula:
C16H15N2NaO6S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cephalothin sodium, a semi-synthetic antibiotic, is derived from cephamycin C, which originates from the bacterial species Cephalosporium acremonium. Its efficacy extends to both Gram-positive and Gram-negative bacteria, as well as anaerobic bacteria. The mechanism of action for cephalothin sodium revolves around inhibiting bacterial cell wall synthesis. It accomplishes this by binding to the penicillin-binding proteins (PBPs) located within the bacterial cell wall, thereby impeding the cross-linking of peptidoglycan chains.
Cephalothin sodium salt (CAS 58-71-9) References
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- Reduction in incidence of methicillin-resistant Staphylococcus aureus (MRSA) after radical surgery for head and neck cancer. | Morimoto, Y., et al. 2006. Spec Care Dentist. 26: 209-13. PMID: 17249442
- Role of outer membrane protein OprD and penicillin-binding proteins in resistance of Pseudomonas aeruginosa to imipenem and meropenem. | Farra, A., et al. 2008. Int J Antimicrob Agents. 31: 427-33. PMID: 18375104
- Detection of outer membrane porin protein, an imipenem influx channel, in Pseudomonas aeruginosa clinical isolates. | Naenna, P., et al. 2010. Southeast Asian J Trop Med Public Health. 41: 614-24. PMID: 20578550
- Local imipenem activity against Pseudomonas aeruginosa decreases in vivo in the presence of siliconized latex. | Pichardo, C., et al. 2011. Eur J Clin Microbiol Infect Dis. 30: 289-91. PMID: 20936490
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- Immunohaematological cross-allergenicity between penicillin and cephalothin in humans. | Abraham, GN., et al. 1968. Clin Exp Immunol. 3: 343-57. PMID: 4172836
- Stability of parenteral solutions of sodium cephalothin, cephaloridine, potassium penicillin G (buffered) and vancomycin hydrochloride. | Mann, JM., et al. 1971. Am J Hosp Pharm. 28: 760-3. PMID: 5125170
- Thrombocytopenia caused by cephalothin sodium. Occurrence in a penicillin-sensitive individual. | Sheiman, L., et al. 1968. JAMA. 203: 601-3. PMID: 5694200
- Intramuscular injection-site complications. | Greenblatt, DJ. and Allen, MD. 1978. JAMA. 240: 542-4. PMID: 671665
- Quantitation of carbenicillin disodium, cefazolin sodium, cephalothin sodium, nafcillin sodium, and ticarcillin disodium by high-pressure liquid chromatography. | Gupta, VD. and Stewart, KR. 1980. J Pharm Sci. 69: 1264-7. PMID: 7452453
- In vitro and in vivo evaluation of BO-2727 against imipenem- and/or meropenem-resistant Pseudomonas aeruginosa. | Shibata, K., et al. 1997. J Antibiot (Tokyo). 50: 135-8. PMID: 9099222
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cephalothin sodium salt, 100 mg | sc-257223 | 100 mg | $35.00 | |||
Cephalothin sodium salt, 250 mg | sc-257223A | 250 mg | $42.00 |