Cephalothin (CAS 153-61-7)
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Alternate Names:
Cephalotin acid
CAS Number:
153-61-7
Molecular Weight:
396.44
Molecular Formula:
C16H16N2O6S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Cephalothin, also known as cefalotin or CET, belongs to the class of organic compounds called cephalosporin 3′-esters. Cephalothin works by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. These PBPs play a role in the assembly and reshaping of the cell wall during cell division. Cephalothin is characterized by its acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of its core structure.
Cephalothin (CAS 153-61-7) References
- Nephrotoxicity associated with cephalothin administration. | Carling, PC., et al. 1975. Arch Intern Med. 135: 797-801. PMID: 1130924
- Nephrotoxicity of combined cephalothin-gentamicin regimen. | Cabanillas, F., et al. 1975. Arch Intern Med. 135: 850-2. PMID: 1130930
- Derivatives of cephalothin that inhibit ampicillin resistant Escherichia coli. | Bartzatt, R., et al. 2007. Med Chem. 3: 45-9. PMID: 17266623
- Review for Analytical Methods for the Determination of Sodium Cephalothin. | Rugani, KS., et al. 2019. Crit Rev Anal Chem. 49: 187-194. PMID: 30518240
- Penetration of cephalothin and cefoxitin into experimental infections with Bacteroides fragilis. | O'Keefe, JP., et al. 1979. Rev Infect Dis. 1: 106-12. PMID: 318211
- Cephalothin: Review of Characteristics, Properties, and Status of Analytical Methods. | Nascimento, PAD., et al. 2021. J AOAC Int. 104: 1593-1608. PMID: 33252646
- Comparative studies of cefoxitin and cephalothin: an overview. | Neu, HC. 1979. Rev Infect Dis. 1: 144-51. PMID: 400931
- Cephalothin Prophylaxis and valve replacement. | Austin, TW., et al. 1977. Ann Thorac Surg. 23: 333-6. PMID: 403867
- Cephalothin: hydrolysis of the C-3'-acetoxy moiety of a 7-aminocephalosporanic acid; observation of both acyl-oxygen bond cleavage and reversible alkyl-oxygen bond cleavage. | Indelicato, JM., et al. 1985. J Pharm Sci. 74: 1162-6. PMID: 4087175
- Immunohaematological cross-allergenicity between penicillin and cephalothin in humans. | Abraham, GN., et al. 1968. Clin Exp Immunol. 3: 343-57. PMID: 4172836
- Renal function and cephalothin. | Thomas, LB. 1969. N Engl J Med. 280: 505-6. PMID: 5763705
- Cefotaxime, cephalothin, and cephapirin: antimicrobial activity and synergy studies of cephalosporins with significant in vivo desacetyl metabolite concentrations. | Jones, RN. and Packer, RR. 1984. Diagn Microbiol Infect Dis. 2: 65-8. PMID: 6100364
- Penetration of cefamandole, cephalothin, and desacetylcephalothin into fibrin clots. | Bergeron, MG., et al. 1977. Antimicrob Agents Chemother. 12: 682-7. PMID: 931366
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cephalothin, 1 g | sc-499197 | 1 g | $44.00 |