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Cephalomannine (CAS 71610-00-9)

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Alternate Names:
Taxol B
Application:
Cephalomannine is a potential antineoplastic compound
CAS Number:
71610-00-9
Molecular Weight:
831.90
Molecular Formula:
C45H53NO14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cephalomannine is a natural product belonging to the taxane family of diterpenoids that is often a subject of interest in organic chemistry research. In the study of natural product synthesis, Cephalomannine is a target for chemists due to its complex structure, which poses a significant synthetic challenge and helps in developing new synthetic methodologies. Its role in the biosynthesis pathways of taxane compounds is also a key area of investigation, with researchers aiming to understand the enzymatic processes that lead to its formation. In addition, Cephalomannine′s potential as a starting material for the synthesis of analogs that could have interesting properties is of significance to researchers looking to expand the diversity of taxane-like molecules. Furthermore, the compound is studied in the context of materials science for its potential incorporation into novel organic compounds with specific optical or electronic properties.


Cephalomannine (CAS 71610-00-9) References

  1. Identification of isocephalomannine in the presence of cephalomannine isomers and alkali metal ion adducts in a paclitaxel active pharmaceutical ingredient using electrospray tandem mass spectrometry.  |  Vivekanandan, K., et al. 2006. Rapid Commun Mass Spectrom. 20: 1731-5. PMID: 16676315
  2. [Studies on the chemical constituents of Taxus yunnanensis].  |  Chen, WM., et al. 1991. Yao Xue Xue Bao. 26: 747-54. PMID: 1688071
  3. Microbial transformation of cephalomannine by Luteibacter sp.  |  Li, J., et al. 2007. J Nat Prod. 70: 1846-9. PMID: 18001087
  4. C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes.  |  Zhang, YY., et al. 2009. Xenobiotica. 39: 903-14. PMID: 19795923
  5. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines.  |  Helson, L. 1993. Int J Oncol. 2: 297-9. PMID: 21573554
  6. [Distribution and variation of paclitaxel and cephalomannine contents in wild Taxus cuspidata].  |  Chang, Z., et al. 2011. Zhongguo Zhong Yao Za Zhi. 36: 294-8. PMID: 21585029
  7. Fatal poisoning with Taxus baccata: quantification of paclitaxel (taxol A), 10-deacetyltaxol, baccatin III, 10-deacetylbaccatin III, cephalomannine (taxol B), and 3,5-dimethoxyphenol in body fluids by liquid chromatography-tandem mass spectrometry.  |  Grobosch, T., et al. 2012. J Anal Toxicol. 36: 36-43. PMID: 22290751
  8. Synthesis, isolation, stereostructure and cytotoxicity of paclitaxel analogs from cephalomannine.  |  Gao, F., et al. 2013. Fitoterapia. 90: 79-84. PMID: 23876369
  9. Chemical studies on Taxus canadensis.  |  Li, Y., et al. 2013. Chem Biodivers. 10: 1729-53. PMID: 24130020
  10. Determination of cephalomannine in rat plasma by gradient elution UPLC-MS/MS method.  |  Wang, XS., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 963: 70-4. PMID: 24929960
  11. Synthesis of Taxol and Docetaxel by Using 10-Deacetyl-7-xylosyltaxanes.  |  Xue, B., et al. 2020. Chem Biodivers. 17: e1900631. PMID: 31967396
  12. UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.  |  Zhang, RY., et al. 2021. Signal Transduct Target Ther. 6: 64. PMID: 33589597
  13. Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer.  |  Ullah, A., et al. 2021. Cell Death Dis. 12: 490. PMID: 33990544
  14. UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer.  |  Peng, S., et al. 2022. Int J Biol Sci. 18: 3528-3543. PMID: 35637955
  15. Sample preparation for taxol and cephalomannine determination in various organs of Taxus sp.  |  Glowniak, K., et al. 1996. J Pharm Biomed Anal. 14: 1215-20. PMID: 8818036

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cephalomannine, 5 mg

sc-205626
5 mg
$347.00

Cephalomannine, 10 mg

sc-205626A
10 mg
$500.00

Cephalomannine, 1 g

sc-205626B
1 g
$1428.00

Cephalomannine, 2 g

sc-205626C
2 g
$2040.00