Centrin-1 Antibody (2A6): sc-293494
- Centrin-1 Antibody (2A6) is a mouse monoclonal IgG1 κ Centrin-1 antibody provided at 100 µg/ml
- raised against amino acids 1-100 representing partial length Centrin-1 of human origin
- recommended for detection of Centrin-1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Centrin-1 Antibody (2A6). This work is in progress.
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Centrin-1 Antibody (2A6) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Centrin-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Centrin-1 antibody (2A6) is available as a non-conjugated format. Centrin-1, also known as Caltractin isoform 2, is a member of the EF-hand type calcium-binding protein family, which includes Centrin-2 and Centrin-3. These proteins are crucial for various cellular functions, particularly in the organization and duplication of centrioles, which are essential for proper cell division. Centrin-1 is predominantly located in the cytoplasm and is associated with centrosomes, mitotic spindle poles, and basal bodies, highlighting its role in maintaining cellular architecture during mitosis. The expression of Centrin-1 is notably increased during cell differentiation, especially in tissues where cilia are present, such as the retina and testis. In these tissues, Centrin-1 works in concert with Centrin-2, which is also found in non-differentiated retinal cells, liver, skeletal muscle, and cardiac muscle. The interaction of Centrin-1 with centrosomes is vital for centriole duplication and spindle pole organization, and knockdown studies have demonstrated that Centrin-1 is necessary for the completion of cytokinesis. Understanding the function and localization of Centrin-1 is important for elucidating its role in cell cycle regulation and potential implications in diseases related to cell division abnormalities.
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Centrin-1 Antibody (2A6) References:
- A role for centrin 3 in centrosome reproduction. | Middendorp, S., et al. 2000. J Cell Biol. 148: 405-16. PMID: 10662768
- Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro. | Laoukili, J., et al. 2000. J Cell Sci. 113 (Pt 8): 1355-64. PMID: 10725219
- Cation- and peptide-binding properties of human centrin 2. | Durussel, I., et al. 2000. FEBS Lett. 472: 208-12. PMID: 10788612
- Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. | Araki, M., et al. 2001. J Biol Chem. 276: 18665-72. PMID: 11279143
- Centrin-2 is required for centriole duplication in mammalian cells. | Salisbury, JL., et al. 2002. Curr Biol. 12: 1287-92. PMID: 12176356
- Centriole duplication: centrin in on answers? | Rice, LM. and Agard, DA. 2002. Curr Biol. 12: R618-9. PMID: 12372266
- C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain. | Matei, E., et al. 2003. Biochemistry. 42: 1439-50. PMID: 12578356
- Calcium and magnesium binding to human centrin 3 and interaction with target peptides. | Cox, JA., et al. 2005. Biochemistry. 44: 840-50. PMID: 15654740
- Expression of centrin isoforms in the mammalian retina. | Wolfrum, U. and Salisbury, JL. 1998. Exp Cell Res. 242: 10-7. PMID: 9665797
- Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells. | LeDizet, M., et al. 1998. Am J Physiol. 275: L1145-56. PMID: 9843852
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Centrin-1 Antibody (2A6) | sc-293494 | 100 µg/ml | $322.00 |