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Ceftriaxone, Disodium Salt, Hemiheptahydrate (CAS 104376-79-6)

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Alternate Names:
Ro-13-9904/001; Rocefin; Rocephine
Application:
Ceftriaxone, Disodium Salt, Hemiheptahydrate is a potentially useful antibacterial agent for proteomics research
CAS Number:
104376-79-6
Purity:
≥92%
Molecular Weight:
661.60
Molecular Formula:
C18H16N8Na2O7S33.5H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ceftriaxone, Disodium Salt, Hemiheptahydrate is used as an antibacterial agent. Ceftriaxone is used to study drug-induced immune hemolytic anemias prophylactic strategies to reduce neonatal encephalopathy pentylenetetrazole-evoked convulsions the effect of expression, binding, and inhibition of PDP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis. Ceftriaxone is a third-generation cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It is effective against gram-positive and gram-negative bacteria. Ceftriaxone is thought to increase EAAT2 pump expression in the central nervous system and to reduce glutamatergic toxicity.


Ceftriaxone, Disodium Salt, Hemiheptahydrate (CAS 104376-79-6) References

  1. Time-kill evaluation of antimicrobial regimens against clinical isolates of penicillin-resistant Streptococcus pneumoniae.  |  Bañón Arias, R., et al. 2001. J Chemother. 13: 535-40. PMID: 11760218
  2. Anaerobic inhibition and biodegradation of antibiotics in ISO test schemes.  |  Gartiser, S., et al. 2007. Chemosphere. 66: 1839-48. PMID: 17097129
  3. Ultimate biodegradation and elimination of antibiotics in inherent tests.  |  Gartiser, S., et al. 2007. Chemosphere. 67: 604-13. PMID: 17166562
  4. Biotic and abiotic degradation of four cephalosporin antibiotics in a lake surface water and sediment.  |  Jiang, M., et al. 2010. Chemosphere. 80: 1399-405. PMID: 20579689
  5. In vitro and in vivo methods to measure the ceftriaxone distribution into the rat tail intervertebral disc.  |  Lin, CC., et al. 2010. Anal Sci. 26: 979-82. PMID: 20834130
  6. In vitro assessment of the formation of ceftriaxone-calcium precipitates in human plasma.  |  Schmutz, HR., et al. 2011. J Pharm Sci. 100: 2300-10. PMID: 21254064
  7. Ceftriaxone Etest non-susceptible methicillin susceptible Staphylococcus aureus time-kill responses.  |  Bremmer, DN., et al. 2017. Diagn Microbiol Infect Dis. 88: 192-194. PMID: 28291629
  8. Ceftriaxone reduces L-dopa-induced dyskinesia severity in 6-hydroxydopamine parkinson's disease model.  |  Chotibut, T., et al. 2017. Mov Disord. 32: 1547-1556. PMID: 28631864
  9. Appliance of fungal chitosan/ceftriaxone nano-composite to strengthen and sustain their antimicrobial potentiality against drug resistant bacteria.  |  Alshubaily, FA. and Al-Zahrani, MH. 2019. Int J Biol Macromol. 135: 1246-1251. PMID: 31181276
  10. Assessment of bacterial viability by laser desorption ionization mass spectrometry for antimicrobial susceptibility testing.  |  Wu, E., et al. 2021. Talanta. 233: 122535. PMID: 34215038
  11. Dual-mode turn-on ratiometric fluorescence sensor based on carbon dots and CuInS2/ZnS quantum dots for detection of chlorotetracycline.  |  Chen, X., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 270: 120851. PMID: 35030415
  12. Ion pair high-performance liquid chromatographic assay for ceftriaxone.  |  Granich, GG. and Krogstad, DJ. 1987. Antimicrob Agents Chemother. 31: 385-8. PMID: 3579254
  13. Enhancement of Acinetobacter baumannii biofilm growth by cephem antibiotics via enrichment of protein and extracellular DNA in the biofilm matrices.  |  Yamabe, K., et al. 2022. J Appl Microbiol. 133: 2002-2013. PMID: 35818769

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ceftriaxone, Disodium Salt, Hemiheptahydrate, 1 g

sc-211050
1 g
$175.00

Ceftriaxone, Disodium Salt, Hemiheptahydrate, 5 g

sc-211050A
5 g
$440.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-211050, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-02-14
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Rated 5 out of 5 by from Krezmien et alKrezmien et al. (PubMed ID 26384120) treated a patient with acute pyelonephritis using the antibacterial, Ceftriaxone, Disodium Salt, Hemiheptahydrate, and found the drug caused gall bladder enlargement. -SCBT Publication Review
Date published: 2015-02-05
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Ceftriaxone, Disodium Salt, Hemiheptahydrate is rated 5.0 out of 5 by 1.
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