Molecular structure of Ceftiofur, CAS Number: 80370-57-6
Ceftiofur (CAS 80370-57-6)
Application:
Ceftiofur is A third generation cephalosporin antibiotic for used in veterinary medicine
CAS Number:
80370-57-6
Purity:
≥99%
Molecular Weight:
523.56
Molecular Formula:
C19H17N5O7S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ceftiofur is a third generation cephalosporin antibiotic for used in veterinary medicine. It is resistant to antibiotic resistance enzyme beta-lactamase. Ceftiofur possesses the ability to bind to and deactivate penicillin-binding proteins (PBPs) situated on the inner cell membrane of bacterial cell walls. These PBPs play a role in the construction and shaping of bacterial cell walls during growth and division. Inactivating PBPs results in a reduction of cross-linkage and rigidity in the peptidoglycan chain, which is vital for strong and rigid bacterial cell walls. As a consequence, the bacterial cells undergo lysis and their cell walls weaken.
Ceftiofur (CAS 80370-57-6) References
- Ceftiofur distribution in plasma and joint fluid following regional limb injection in cattle. | Navarre, CB., et al. 1999. J Vet Pharmacol Ther. 22: 13-9. PMID: 10211712
- Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-kappaB and MAPK. | Ci, X., et al. 2008. Biochem Biophys Res Commun. 372: 73-7. PMID: 18474228
- Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. | Ci, X., et al. 2008. Inflammation. 31: 422-7. PMID: 18989766
- Ceftiofur attenuates lipopolysaccharide-induced acute lung injury. | Chu, X., et al. 2010. Int Immunopharmacol. 10: 600-4. PMID: 20193778
- Can the unauthorised use of ceftiofur be detected in poultry? | Heinrich, K., et al. 2013. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30: 1733-8. PMID: 23869819
- Ceftiofur pharmacokinetics in Nile tilapia Oreochromis niloticus after intracardiac and intramuscular administrations. | Khalil, WF., et al. 2016. Dis Aquat Organ. 121: 29-35. PMID: 27596857
- Assessment of ceftiofur residues in cow milk using commercial screening test kits. | Durel, L., et al. 2019. Vet Rec Open. 6: e000329. PMID: 31205727
- Pharmacokinetics of ceftiofur sodium in cats following a single intravenous and subcutaneous injection. | Zhang, M., et al. 2019. J Vet Pharmacol Ther. 42: 602-608. PMID: 31529627
- Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers. | Foster, DM., et al. 2019. PLoS One. 14: e0223378. PMID: 31584976
- Effect of ceftiofur on mesophilic anaerobic digestion of dairy manure and the reduction of the cephalosporin-resistance gene cmy-2. | Flores-Orozco, D., et al. 2020. Bioresour Technol. 301: 122729. PMID: 31931335
- Pharmacokinetics of ceftiofur sodium in Peekapoo dogs following a single intravenous and subcutaneous injection. | Yang, F., et al. 2020. J Vet Pharmacol Ther. 43: 325-330. PMID: 32281146
- Impact of Ceftiofur Administration in Steers on the Prevalence and Antimicrobial Resistance of Campylobacter spp. | Fan, S., et al. 2021. Microorganisms. 9: PMID: 33557120
- Pharmacokinetics of ceftiofur in the metacarpophalangeal joint after standing intravenous regional limb perfusion in horses. | Bonilla, AG., et al. 2021. Can Vet J. 62: 975-981. PMID: 34475583
- Optimization and Validation of Dosage Regimen for Ceftiofur against Pasteurella multocida in Swine by Physiological Based Pharmacokinetic-Pharmacodynamic Model. | Mi, K., et al. 2022. Int J Mol Sci. 23: PMID: 35409082
- Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. | Ahmadvand, P., et al. 2022. Int J Mol Sci. 23: PMID: 35563620
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ceftiofur, 100 mg | sc-234293 | 100 mg | $75.00 |