Ceftibuten Hydrate (CAS 97519-39-6)

Ceftibuten hydrate, a third-generation cephalosporin antibiotic, has been extensively investigated in scientific research for its antimicrobial activity and mechanism of action. Studies have explaind that ceftibuten inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), particularly PBPs involved in peptidoglycan cross-linking during cell wall assembly. This binding disrupts the transpeptidation reaction, leading to the inhibition of bacterial cell wall formation and ultimately bacterial growth inhibition. In research applications, ceftibuten hydrate has been utilized to investigate bacterial cell wall biosynthesis, mechanisms of antibiotic resistance, and the development of novel antimicrobial agents. It has been instrumental in elucidating the molecular basis of cephalosporin resistance, such as mutations in PBPs or upregulation of efflux pumps. Additionally, ceftibuten hydrate has been employed in studies exploring strategies to enhance antibiotic efficacy or overcome resistance mechanisms, offering valuable insights into the development of novel antimicrobial agents. Moreover, its specific mechanism of action and potent antibacterial properties make ceftibuten hydrate a valuable compound in antimicrobial research, contributing to the understanding of bacterial physiology and the development of novel strategies aimed at combating drug-resistant bacterial infections.