Cefteram Pivoxil (CAS 82547-81-7)

Cefteram Pivoxil, with the CAS number 82547-81-7, is an esterified prodrug form of the cephalosporin antibiotic cefteram. This chemical modification enhances the oral bioavailability of the compound. Once administered, cefteram pivoxil is metabolized in the body to release cefteram, which is the active moiety. Cefteram exerts its antibacterial action primarily through the inhibition of bacterial cell wall synthesis, a critical process for bacterial cell viability. It achieves this by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. These PBPs play a crucial role in the final stages of assembling the bacterial cell wall and in reshaping during cell growth and division. By inhibiting these proteins, cefteram disrupts the cell wall synthesis, leading to cell lysis and bacterial death. In research settings, cefteram pivoxil has been extensively utilized to study the pharmacokinetics and dynamics of prodrug conversion in cephalosporins, offering insights into how esterification can be used to enhance drug delivery and absorption. Furthermore, research involving this compound has contributed to understanding the spectrum of activity against various bacterial pathogens and the mechanisms underlying resistance to cephalosporin antibiotics. Such studies are pivotal in guiding the development of next-generation cephalosporins to combat resistant bacterial strains effectively.