Ceftazidime-d5 (CAS 72558-82-8 (unlabeled))

Ceftazidime-d5 is a deuterated form of ceftazidime, a third-generation cephalosporin antibiotic known for its broad-spectrum activity against Gram-negative bacteria. Incorporating deuterium, a stable isotope of hydrogen, ceftazidime-d5 is primarily used in scientific research to investigate the pharmacokinetics and metabolic pathways of ceftazidime without the intent of therapeutic application. The substitution of hydrogen atoms with deuterium in the molecular structure does not significantly alter the chemical properties of the drug but does increase the molecular weight slightly and can affect the rate of metabolic degradation, often slowing it down. This characteristic makes ceftazidime-d5 an ideal candidate for use as an internal standard in mass spectrometric analysis, allowing researchers to achieve more precise measurements of ceftazidime in biological samples by comparing it to the deuterated version, which behaves similarly in the system but can be distinguished based on its mass difference. In research settings, the use of ceftazidime-d5 helps to explain how ceftazidime is absorbed, distributed, metabolized, and excreted in living organisms, providing essential data that can enhance the understanding of its pharmacological attributes and optimize its clinical efficacy. This type of study is crucial for developing dosing regimens that maximize therapeutic effects while minimizing potential side effects.