Cefprozil (CAS 92665-29-7)

Cefprozil, identified by CAS number 92665-29-7, is a second-generation cephalosporin that has been extensively used in microbiological research to study the dynamics of bacterial cell wall synthesis and the mechanisms of bacterial resistance. Cefprozil functions by targeting and inhibiting specific penicillin-binding proteins (PBPs), which are crucial enzymes involved in the biosynthesis of the bacterial cell wall. These PBPs catalyze the cross-linking of peptidoglycan layers that provide structural integrity to the bacterial cell wall. By binding to these PBPs, cefprozil interferes with the normal construction process of the cell wall, resulting in the weakening and eventual rupture of the wall, leading to bacterial cell lysis and death. In research contexts, cefprozil is particularly valuable for its efficacy against a broad range of Gram-positive and some Gram-negative bacteria, which allows for comparative studies on PBP target specificity and the impact of structural variations on antibiotic efficacy. Additionally, cefprozil has been employed in studies focused on the evolution of beta-lactamase enzymes, particularly those that confer resistance to cephalosporins. Through such research, insights into genetic mutations that lead to enhanced bacterial resistance are gained, aiding in the development of strategies to counteract these resistant strains and to understand the molecular basis of antibiotic action further.