Molecular structure of Cefepime Dihydrochloride Monohydrate, CAS Number: 123171-59-5
Cefepime Dihydrochloride Monohydrate (CAS 123171-59-5)
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Alternate Names:
Axepim; Cepimex; Maxipime
Application:
Cefepime Dihydrochloride Monohydrate is a fourth generation cephalosporin antibacterial
CAS Number:
123171-59-5
Purity:
87.0% of cefepime per mg on anhydrous basis
Molecular Weight:
571.50
Molecular Formula:
C19H24N6O5S2•2HCl•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Cefepime Dihydrochloride Monohydrate is a compound frequently studied in the field of microbiology for its action against a broad spectrum of Gram-positive and Gram-negative bacteria. Research on this compound often focuses on its bactericidal activity, analyzing the mechanisms by which it binds to penicillin-binding proteins and disrupts cell wall synthesis. Studies also examine the efficacy of Cefepime Dihydrochloride Monohydrate against organisms producing extended-spectrum beta-lactamases (ESBLs) and its stability in the presence of these enzymes. In addition, it is used in investigations of bacterial resistance, particularly the genetic and biochemical factors that contribute to decreased susceptibility to beta-lactam antibiotics.
Cefepime Dihydrochloride Monohydrate (CAS 123171-59-5) References
- Stability of cefepime dihydrochloride monohydrate in solid state. | Musiał, W. and Zajac, M. 2002. Acta Pol Pharm. 59: 243-6. PMID: 12403297
- Application of the ion pair concept to the n-octanol-water partitioning of cefepime and cefpirome. | Koufopoulou, SA., et al. 2006. Int J Pharm. 316: 52-7. PMID: 16564653
- Identification and characterization of new degradation products of cefepime dihydrochloride monohydrate drug substance during stress stability studies. | Jagadeesh Kumar, V., et al. 2010. Anal Sci. 26: 1081-6. PMID: 20953052
- An MEKC assay for the therapeutic drug monitoring of cefepime. | Theurillat, R., et al. 2013. J Sep Sci. 36: 2915-21. PMID: 23857909
- Quantification of piperacillin, tazobactam, cefepime, meropenem, ciprofloxacin and linezolid in serum using an isotope dilution UHPLC-MS/MS method with semi-automated sample preparation. | Zander, J., et al. 2015. Clin Chem Lab Med. 53: 781-91. PMID: 25301676
- Therapeutic drug monitoring of cefepime with micellar electrokinetic capillary chromatography: Assay improvement, quality assurance, and impact on patient drug levels. | Theurillat, R., et al. 2016. J Sep Sci. 39: 2626-32. PMID: 27130081
- Simultaneous Determination of Eight β-Lactam Antibiotics, Amoxicillin, Cefazolin, Cefepime, Cefotaxime, Ceftazidime, Cloxacillin, Oxacillin, and Piperacillin, in Human Plasma by Using Ultra-High-Performance Liquid Chromatography with Ultraviolet Detection. | Legrand, T., et al. 2016. Antimicrob Agents Chemother. 60: 4734-42. PMID: 27216076
- 3-Hydroxy-3-methylglutaric aciduria with bilateral basal ganglia lesion: A case report. | Hao, X., et al. 2016. Exp Ther Med. 11: 2573-2576. PMID: 27284350
- Monitoring of cefepime in human serum and plasma by micellar electrokinetic capillary chromatography: Improvement of sample preparation and validation by liquid chromatography coupled to mass spectrometry. | Šestáková, N., et al. 2017. J Sep Sci. 40: 1805-1814. PMID: 28217952
- Identification and determination of related substances of ceftaroline fosamil in medicinal product by high performance liquid chromatography with diode array detection and tandem mass spectrometry. | Karpiuk, I., et al. 2017. J Pharm Biomed Anal. 145: 651-660. PMID: 28800526
- Monitoring of cefepime in urine by micellar electrokinetic capillary chromatography with ultraviolet detection and liquid chromatography coupled to mass spectrometry. | Kummer, M., et al. 2018. J Sep Sci. 41: 4067-4074. PMID: 30198147
- Structure-based identification of small molecules against influenza A virus endonuclease: an in silico and in vitro approach. | K, SD., et al. 2020. Pathog Dis. 78: PMID: 32614388
- Optimising an Infusion Protocol Containing Cefepime to Limit Particulate Load to Newborns in a Neonatal Intensive Care Unit. | Martin Mena, A., et al. 2021. Pharmaceutics. 13: PMID: 33800228
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cefepime Dihydrochloride Monohydrate, 10 mg | sc-211040 | 10 mg | $242.00 |