Date published: 2025-9-28

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Cefazolin sodium salt (CAS 27164-46-1)

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Alternate Names:
monosodium cephazolin
Application:
Cefazolin sodium salt is an inhibitor of bacterial cell wall synthesis
CAS Number:
27164-46-1
Purity:
≥97%
Molecular Weight:
476.49
Molecular Formula:
C14H13N8O4S3•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cefazolin sodium salt is a compound extensively used in the field of analytical chemistry and biochemistry for method development and testing. In research laboratories, it serves as a standard for developing and calibrating chromatographic methods aimed at detecting and quantifying beta-lactam antibiotics in various samples. Its stability in solution and ionic nature make it suitable for use in aqueous mobile phases in high-performance liquid chromatography (HPLC). Furthermore, cefazolin sodium salt is employed in studies concerning the stability and degradation of beta-lactam antibiotics, where researchers observe the effects of environmental factors such as pH, temperature, and light exposure. In biochemical research, it is used to investigate the binding interactions between beta-lactam antibiotics and proteins, including bacterial enzymes and mammalian serum proteins. Additionally, cefazolin sodium salt is a reference compound in the development of biosensors for the rapid detection of antibiotic residues.


Cefazolin sodium salt (CAS 27164-46-1) References

  1. Confirmatory assay for the simultaneous detection of penicillins and cephalosporins in milk using liquid chromatography/tandem mass spectrometry.  |  Daeseleire, E., et al. 2000. Rapid Commun Mass Spectrom. 14: 1404-9. PMID: 10920362
  2. NMR spectroscopic analysis of 2-mercapto-5-methyl-1,3,4-thiadiazole in cefazolin.  |  Staiger, DB., et al. 1975. J Pharm Sci. 64: 1396-7. PMID: 1151715
  3. Strategies for the determination of cefazolin in plasma and microdialysis samples by short-end capillary zone electrophoresis.  |  Mayer, BX., et al. 2003. Electrophoresis. 24: 1215-20. PMID: 12707914
  4. Therapeutic dose of acetaminophen as a possible risk factor for acute kidney injury: learning from two healthy young adult cases.  |  Kato, H., et al. 2014. Intern Med. 53: 1531-4. PMID: 25030567
  5. Recovery with a regular dose of antibiotics from bacillary hemoglobinuria in a Holstein cow.  |  Takagi, M., et al. 2016. J Vet Med Sci. 78: 1737-1740. PMID: 27498996
  6. Simultaneous Determination of Cefalexin, Cefazolin, Flucloxacillin, and Probenecid by Liquid Chromatography-Tandem Mass Spectrometry for Total and Unbound Concentrations in Human Plasma.  |  Zhang, M., et al. 2018. Ther Drug Monit. 40: 682-692. PMID: 30015652
  7. In vitro antimicrobial activity against equine Lawsonia intracellularis strains.  |  Pereira, CER., et al. 2019. Equine Vet J. 51: 665-668. PMID: 30629755
  8. Preparation of a novel clay loaded with Fe (VI) for degradation of cefazolin: performance, pathway, and mechanism.  |  Zhou, M., et al. 2022. Environ Sci Pollut Res Int. 29: 46259-46272. PMID: 35167022
  9. An ultra sensitive and rapid SERS detection method based on vortex aggregation enhancement effect for anti-infective drug residues detection in water.  |  Zheng, X., et al. 2022. Anal Chim Acta. 1235: 340539. PMID: 36368827
  10. PS-5, a new beta-lactam antibiotic. II. Antimicrobial activity.  |  Sakamoto, M., et al. 1979. J Antibiot (Tokyo). 32: 272-9. PMID: 38238
  11. Cefazolin, a new semisynthetic cephalosporin antibiotic. II. In vitro and in vivo antimicrobial activity.  |  Nishida, M., et al. 1970. J Antibiot (Tokyo). 23: 137-48. PMID: 4394125
  12. The effect of beta-lactamase stability, penetration, and target affinity on the activity of cefazolin, cefamandole, cefoxitin, and cefuroxime.  |  Harper, PB. 1984. Clin Ther. 6: 310-24. PMID: 6609771
  13. Layered double hydroxide as novel antibacterial drug delivery system  |  SJ Ryu, H Jung, JM Oh, JK Lee, JH Choy -. April 2010,. Journal of Physics and Chemistry of Solids. Volume 71, Issue 4: Pages 685-688.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cefazolin sodium salt, 250 mg

sc-202533
250 mg
$53.00

Cefazolin sodium salt, 1 g

sc-202533A
1 g
$162.00