Date published: 2026-5-1

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Cefadroxil (CAS 50370-12-2)

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Alternate Names:
Cefadroxilo; Cefadroxilum; Duricef
CAS Number:
50370-12-2
Molecular Weight:
363.39
Molecular Formula:
C16H17N3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cefadroxil is a first-generation cephalosporin with antibacterial activity. It binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.


Cefadroxil (CAS 50370-12-2) References

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  2. Impact of lipopolysaccharide-induced inflammation on the disposition of the aminocephalosporin cefadroxil.  |  Huh, Y., et al. 2013. Antimicrob Agents Chemother. 57: 6171-8. PMID: 24080658
  3. Determination of cefadroxil in rat plasma and urine using LC-MS/MS and its application to pharmacokinetic and urinary excretion studies.  |  Jin, HE., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 947-948: 103-10. PMID: 24412692
  4. Characteristics, Properties and Analytical Methods of Cefadroxil: A Review.  |  de Marco, BA. and Salgado, HR. 2017. Crit Rev Anal Chem. 47: 93-98. PMID: 27494757
  5. Controlled release of organic-inorganic nanohybrid:cefadroxil intercalated Zn-Al-layered double hydroxide.  |  Khan, SB., et al. 2018. Int J Nanomedicine. 13: 3203-3222. PMID: 29881273
  6. Derivative constant wavelength synchronous fluorescence spectrometry for the simultaneous detection of cefadrine and cefadroxil in water samples.  |  Elbalkiny, HT., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 229: 117903. PMID: 31887677
  7. A Critical Review of Cephalexin and Cefadroxil for the Treatment of Acute Uncomplicated Lower Urinary Tract Infection in the Era of 'Bad Bugs, Few Drugs'.  |  Nguyen, HM. and Graber, CJ. 2020. Int J Antimicrob Agents. 56: 106085. PMID: 32659466
  8. Physiologically Based Pharmacokinetic Modeling of Cefadroxil in Mouse, Rat, and Human to Predict Concentration-Time Profile at Infected Tissue.  |  Tan, Z., et al. 2021. Front Pharmacol. 12: 692741. PMID: 35002687
  9. Cefadroxil. A review of its antibacterial, pharmacokinetic and therapeutic properties in comparison with cephalexin and cephradine.  |  Tanrisever, B. and Santella, PJ. 1986. Drugs. 32 Suppl 3: 1-16. PMID: 3542485
  10. Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections.  |  Haynes, AS., et al. 2022. Microbiol Spectr. 10: e0103922. PMID: 35730963
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  12. Cefadroxil in the horse: pharmacokinetics and in vitro antibacterial activity.  |  Wilson, WD., et al. 1985. J Vet Pharmacol Ther. 8: 246-53. PMID: 4057345
  13. Influence of dose on the pharmacokinetics of cefadroxil.  |  Mariño, EL. and Dominguez-Gil, A. 1980. Eur J Clin Pharmacol. 18: 505-9. PMID: 7461017
  14. Nonlinear pharmacokinetics of cefadroxil in the rat.  |  García-Carbonell, MC., et al. 1993. Drug Metab Dispos. 21: 215-7. PMID: 8097688
  15. Cefadroxil, a new broad-spectrum cephalosporin.  |  Buck, RE. and Price, KE. 1977. Antimicrob Agents Chemother. 11: 324-30. PMID: 848939

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cefadroxil, 1 g

sc-495843
1 g
$65.00