CEACAM1/3/6 Antibody (3H2379): sc-70757

CEACAM1/3/6 Antibody (3H2379) is a rat monoclonal IgG2a antibody that detects CEACAM1/3/6 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CEACAM1/3/6 is part of the carcinoembryonic antigen (CEA) family, which plays a crucial role in cell adhesion and signaling processes, particularly in tumor biology. These glycoproteins are predominantly expressed in epithelial tissues and are known to be upregulated in various cancers, making them significant biomarkers for tumor progression and metastasis. CEACAM proteins are located on the cell surface, where they facilitate intercellular adhesion and communication, which is vital for maintaining tissue architecture and regulating immune responses. Notably, CEACAM1′s interaction with other proteins, such as the immune checkpoint receptor PD-1, highlights CEACAM1′s importance in modulating immune responses, particularly in the tumor microenvironment. CEACAM1/3/6′s ability to mediate both homotypic and heterotypic adhesion events underscores CEACAM1/3/6′s potential as a therapeutic target and valuable marker for cancer diagnostics.

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CEACAM1/3/6 Antibody (3H2379) References:

1. The UspA1 protein of Moraxella catarrhalis induces CEACAM-1-dependent apoptosis in alveolar epithelial cells.  |  N'Guessan, PD., et al. 2007. J Infect Dis. 195: 1651-60. PMID: 17471435
2. Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease.  |  Callaghan, MJ., et al. 2008. Genes Immun. 9: 30-7. PMID: 17960155
3. Two new synthetic peptides from the N-domain of CEACAM1 (CD66a) stimulate neutrophil adhesion to endothelial cells.  |  Skubitz, KM. and Skubitz, AP. 2011. Biopolymers. 96: 25-31. PMID: 20560140
4. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis.  |  Beauchemin, N. and Arabzadeh, A. 2013. Cancer Metastasis Rev. 32: 643-71. PMID: 23903773
5. Carcinoembryonic antigen (CEACAM) family members and Inflammatory Bowel Disease.  |  Kelleher, M., et al. 2019. Cytokine Growth Factor Rev. 47: 21-31. PMID: 31133507
6. CEACAM Gene Family Mutations Associated With Inherited Breast Cancer Risk - A Comparative Oncology Approach to Discovery.  |  Huskey, ALW., et al. 2021. Front Genet. 12: 702889. PMID: 34447411
7. Antibody ligation of CEACAM1, CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans.  |  Klaile, E., et al. 2022. Cell Immunol. 371: 104459. PMID: 34847408
8. CEACAM-1 Induced CSF3-receptor Downregulation in Bone Marrow Associated With Refractory Neutropenia in Advanced Cirrhosis.  |  Bihari, C., et al. 2022. J Clin Transl Hepatol. 10: 53-62. PMID: 35233373
9. CEACAM expression in an in-vitro prostatitis model.  |  Kube-Golovin, I., et al. 2023. Front Immunol. 14: 1236343. PMID: 37691945
10. New CEACAM-targeting 2A3 single-domain antibody-based chimeric antigen receptor T-cells produce anticancer effects in vitro and in vivo.  |  Jancewicz, I., et al. 2024. Cancer Immunol Immunother. 73: 30. PMID: 38279989

The preferred CEACAM6 antibody is CEACAM6 Antibody (9A6): sc-59899.