Cdx4 Antibody (C-7): sc-374472

Cdx4 Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects Cdx4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cdx4 is a crucial transcription factor that plays a significant role in embryonic development by regulating the expression of Hox genes, which are essential for the proper formation of various structures in vertebrates, including the central nervous system, heart, and limbs. Cdx4 is primarily located in the nucleus, where Cdx4 binds to DNA and influences gene expression, making localization vital for developmental processes. Notably, Cdx4 acts as a major positive regulator of all Hox family members and is directly targeted by the canonical Wnt signaling pathway, which is integral to cell fate determination and tissue patterning. Dysregulation of Cdx4 can lead to severe developmental anomalies, such as an expanded hindbrain or loss of segmental features, underscoring Cdx4′s importance in maintaining vertebrate morphology. anti-Cdx4 antibody (C-7) is an invaluable tool for researchers studying developmental biology and gene regulation, providing insights into the mechanisms underlying vertebrate development and potential implications in developmental disorders.

The preferred Cdx4 antibody is Cdx4 Antibody (H-4): sc-374471.