Cdx1 Antibody (286.4): sc-130363
- Cdx1 Antibody (286.4) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant Cdx1 of human origin
- recommended for detection of Cdx1 of human origin by IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cdx1 Antibody (286.4). This work is in progress.
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Cdx1 Antibody (286.4) is a mouse monoclonal IgG2a antibody that detects Cdx1 in human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Cdx1 is a crucial transcription factor that plays a significant role in the development and differentiation of intestinal epithelial cells. Cdx1 is primarily located in the nucleus of intestinal cells, where Cdx1 regulates gene expression essential for maintaining the intestinal phenotype and promoting cellular growth. The proper localization of Cdx1 is vital, as Cdx1 ensures effective interaction with target genes involved in intestinal development and function. Notably, Cdx1 expression levels are closely linked to the anterior-posterior patterning of the intestinal epithelium, influencing patterns of proliferation and differentiation along the crypt-villus axis. Furthermore, a decrease in Cdx1 expression has been associated with colorectal tumorigenesis, highlighting Cdx1′s importance in maintaining normal intestinal function and preventing cancer progression. The human Cdx1 gene, located on chromosome 5q31-q33, encodes a 265-amino acid protein, and Cdx1 expression is essential for the regulation of intestinal homeostasis. anti-Cdx1 antibody (286.4) is an invaluable tool for researchers studying intestinal biology and related diseases, providing insights into the mechanisms of intestinal development and the potential implications of Cdx1 in colorectal cancer.
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Cdx1 Antibody (286.4) References:
- Cdx1 inhibits the proliferation of human colon cancer cells by reducing cyclin D1 gene expression. | Lynch, J., et al. 2003. Oncogene. 22: 6395-407. PMID: 14508520
- Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. | Wong, NA., et al. 2004. Proc Natl Acad Sci U S A. 101: 574-9. PMID: 14704280
- Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. | Béland, M., et al. 2004. Mol Cell Biol. 24: 5028-38. PMID: 15143193
- Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine. | Grainger, S., et al. 2013. PLoS One. 8: e54757. PMID: 23382958
- CDX1 restricts the invasion of HTR-8/SVneo trophoblast cells by inhibiting MMP-9 expression. | Jia, RZ., et al. 2014. Placenta. 35: 450-4. PMID: 24836459
- A novel role of CDX1 in embryonic epicardial development. | Chu, M., et al. 2014. PLoS One. 9: e103271. PMID: 25068460
- The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation. | Jones, MF., et al. 2015. Proc Natl Acad Sci U S A. 112: E1550-8. PMID: 25775580
- Low CDX1 expression predicts a poor prognosis for hepatocellular carcinoma patients after hepatectomy. | Zheng, H., et al. 2016. Surg Oncol. 25: 171-7. PMID: 27566019
- Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression. | Luk, IY., et al. 2022. Cell Death Differ. 29: 2288-2302. PMID: 35606410
- The effect of miR-372-5p regulation on CDX1 and CDX2 in the gastric cancer cell line. | Gharakhyli, EA., et al. 2023. Horm Mol Biol Clin Investig. 44: 271-276. PMID: 36848481
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdx1 Antibody (286.4) | sc-130363 | 100 µg/ml | $333.00 |