CDV surface envelope antigen Antibody (5-4): sc-51812

CDV surface envelope antigen Antibody (5-4) is a mouse monoclonal IgG2a antibody that detects CDV surface envelope antigen of CDV origin by enzyme-linked immunosorbent assay (ELISA). Anti-CDV surface envelope antigen antibody (5-4) is available in a non-conjugated form, specifically designed for detecting the viral protein that plays a crucial role in viral invasion of host cells. Canine distemper virus (CDV), a member of the Morbillivirus genus, poses a significant threat to dogs and other carnivores, particularly affecting those between four months and four years old. CDV surface envelope antigen is essential for virus′s ability to attach to and penetrate host cells, facilitating subsequent replication of CDV within the central nervous system. Once inside, CDV targets glial cells and neurons, leading to viral-induced immunosuppression that can result in severe neurological damage, including demyelination. This process is particularly concerning as it can culminate in encephalomyelitis, a common cause of mortality associated with CDV infection. CDV persistence in the brain, characterized by non-cytolytic selective spread with limited viral budding, underscores the importance of monitoring CDV surface envelope antigen for effective diagnosis and research into potential therapeutic interventions.

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CDV surface envelope antigen Antibody (5-4) References:

1. DNA vaccine encoding nucleocapsid and surface proteins of wild type canine distemper virus protects its natural host against distemper.  |  Cherpillod, P., et al. 2000. Vaccine. 18: 2927-36. PMID: 10825593
2. Canine distemper virus in seals.  |  Osterhaus, AD., et al. 1988. Nature. 335: 403-4. PMID: 3419515
3. Canine distemper virus: review of structural and functional modulations in lymphoid tissues.  |  Krakowka, S., et al. 1980. Am J Vet Res. 41: 284-92. PMID: 6989302
4. Demyelination in experimental canine distemper virus infection: immunological, pathologic, and immunohistological studies.  |  Vandevelde, M., et al. 1982. Acta Neuropathol. 56: 285-93. PMID: 7090737
5. Detection of canine distemper virus nucleocapsid protein gene in canine peripheral blood mononuclear cells by RT-PCR.  |  Shin, Y., et al. 1995. J Vet Med Sci. 57: 439-45. PMID: 7548395
6. Aspects of canine distemper virus and measles virus encephalomyelitis.  |  Summers, BA. and Appel, MJ. 1994. Neuropathol Appl Neurobiol. 20: 525-34. PMID: 7898614
7. The neurobiology of canine distemper virus infection.  |  Vandevelde, M. and Zurbriggen, A. 1995. Vet Microbiol. 44: 271-80. PMID: 8588322
8. Canine distemper virus--a morbillivirus in search of new hosts?  |  Harder, TC. and Osterhaus, AD. 1997. Trends Microbiol. 5: 120-4. PMID: 9080611

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CDV surface envelope antigen Antibody (5-4) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CDV surface envelope antigen Antibody (5-4) Specifications

Alternate Product Name: CDV surface envelope antigen

Product Clone Name: 5-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: CDV surface envelope antigen

Epitope Species: CDV

Product Reactivity/Detection: surface envelope antigen

Species Reactivity/Detection: CDV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CDV surface envelope antigen Antibody (5-4): N/A