CDSN Antibody (C-3): sc-514845

CDSN Antibody (C-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects CDSN protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CDSN antibody (C-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Corneodesmosin (CDSN), also known as S protein, plays a crucial role in the formation of corneodesmosomes, which are essential for maintaining the structural integrity of the skin by facilitating the adhesion of corneocytes. CDSN is exclusively expressed in the skin, particularly in differentiating keratinocytes, and CDSN expression is closely linked to psoriasis susceptibility, a complex inflammatory skin condition. The CDSN gene, which consists of two exons, encodes a protein of 486 amino acids, including a putative 16-amino acid signal sequence, and exhibits homology to other key structural proteins such as Loricrin, Cytokeratin 1, and Cytokeratin 10, all of which are integral components of the skin′s granular layer. Understanding CDSN function is vital, as CDSN not only contributes to skin barrier function but also serves as a potential biomarker for psoriasis, highlighting CDSN importance in dermatological research and therapeutic development.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CDSN Antibody (C-3) References:

1. A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups.  |  Capon, F., et al. 2004. Hum Mol Genet. 13: 2361-8. PMID: 15333584
2. Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice.  |  Yang, T., et al. 2004. Genes Dev. 18: 2354-8. PMID: 15466487
3. Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-Kb interval around the corneodesmosin gene (CDSN).  |  Orrù, S., et al. 2005. Am J Hum Genet. 76: 164-71. PMID: 15529278
4. The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis.  |  Allen, MH., et al. 2005. J Invest Dermatol. 124: 103-6. PMID: 15654960
5. Corneodesmosin polymorphisms in psoriatic arthritis.  |  Butt, C., et al. 2005. Rheumatology (Oxford). 44: 684-5. PMID: 15716318
6. Corneodesmosin (CDSN) gene association with psoriasis vulgaris in Caucasian but not in Japanese populations.  |  Ameen, M., et al. 2005. Clin Exp Dermatol. 30: 414-8. PMID: 15953084
7. Human hair abnormalities resulting from inherited desmosome gene mutations.  |  McGrath, JA. and Wessagowit, V. 2005. Keio J Med. 54: 72-9. PMID: 16077256
8. Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.  |  Helms, C., et al. 2005. Hum Genet. 118: 466-76. PMID: 16235096
9. The region of 150 kb telometic to HLA-C is associated with psoriasis in the Jewish population.  |  Martínez-Borra, J., et al. 2005. J Invest Dermatol. 125: 928-32. PMID: 16297191
10. A non-sense mutation in the corneodesmosin gene in a Mexican family with hypotrichosis simplex of the scalp.  |  Dávalos, NO., et al. 2005. Br J Dermatol. 153: 1216-9. PMID: 16307662

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CDSN Antibody (C-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CDSN Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CDSN Antibody (C-3) Specifications

Alternate Product Name: CDSN

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 204-227

Epitope Target: CDSN

Epitope Species: mouse

Product Reactivity/Detection: CDSN

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CDSN Antibody (C-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin