Molecular structure of cDPCP, CAS Number: 106343-54-8
cDPCP (CAS 106343-54-8)
Alternate Names:
Pyriplatin
Application:
cDPCP is a tumor cell permeable, potent platinum-based antineoplastic agent
CAS Number:
106343-54-8
Purity:
≥95%
Molecular Weight:
379.14
Molecular Formula:
C5H11Cl2PtN3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
cDPCP, also known as diphenylcyclopropenone, is a small molecule that is used in laboratories for its ability to induce contact dermatitis in animal models. cDPCP is a potent sensitizer, meaning it can trigger an immune response in the skin upon contact. cDPCP is used to study the mechanisms of allergic reactions and immune responses in the skin. In biochemistry, cDPCP is utilized to investigate the signaling pathways and molecular events involved in the development of contact dermatitis. cDPCP is useful for studying the molecular basis of skin inflammation.
cDPCP (CAS 106343-54-8) References
- cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. | Lovejoy, KS., et al. 2008. Proc Natl Acad Sci U S A. 105: 8902-7. PMID: 18579768
- X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct. | Wang, D., et al. 2010. Proc Natl Acad Sci U S A. 107: 9584-9. PMID: 20448203
- Recognition of platinum-DNA damage by poly(ADP-ribose) polymerase-1. | Zhu, G., et al. 2010. Biochemistry. 49: 6177-83. PMID: 20550106
- Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice. | Li, S., et al. 2011. Pharm Res. 28: 610-25. PMID: 21104302
- Spectrum of cellular responses to pyriplatin, a monofunctional cationic antineoplastic platinum(II) compound, in human cancer cells. | Lovejoy, KS., et al. 2011. Mol Cancer Ther. 10: 1709-19. PMID: 21750216
- Monofunctional platinum-DNA adducts are strong inhibitors of transcription and substrates for nucleotide excision repair in live mammalian cells. | Zhu, G., et al. 2012. Cancer Res. 72: 790-800. PMID: 22180496
- Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile. | Park, GY., et al. 2012. Proc Natl Acad Sci U S A. 109: 11987-92. PMID: 22773807
- Understanding and improving platinum anticancer drugs--phenanthriplatin. | Johnstone, TC., et al. 2014. Anticancer Res. 34: 471-6. PMID: 24403503
- Bio-inspired polymer envelopes around adenoviral vectors to reduce immunogenicity and improve in vivo kinetics. | Fan, G., et al. 2016. Acta Biomater. 30: 94-105. PMID: 26546972
- The influence of the ethane-1,2-diamine ligand on the activity of a monofunctional platinum complex. | Graziotto, ME., et al. 2017. J Inorg Biochem. 177: 328-334. PMID: 28789807
- Anti-cancer characteristics and ototoxicity of platinum(II) amine complexes with only one leaving ligand. | Monroe, JD., et al. 2018. PLoS One. 13: e0192505. PMID: 29513752
- DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin. | Almaqwashi, AA., et al. 2019. J Am Chem Soc. 141: 1537-1545. PMID: 30599508
- The monofunctional platinum(II) compounds, phenanthriplatin and pyriplatin, modulate apoptosis signaling pathways in HEI-OC1 auditory hybridoma cells. | Monroe, JD., et al. 2020. Neurotoxicology. 79: 104-109. PMID: 32413439
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cDPCP, 2.5 mg | sc-214675 | 2.5 mg | $480.00 |