Date published: 2026-1-9

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Cdk4 Inhibitor III (CAS 265312-55-8)

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Alternate Names:
Ryuvidine; 2-methyl-5-(p-tolylamino)benzo[d]thiazole-4,7-dione
Application:
Cdk4 Inhibitor III is a cell-permeable, selective Cdk4 inhibitor
CAS Number:
265312-55-8
Purity:
≥98%
Molecular Weight:
284.33
Molecular Formula:
C15H12N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cdk4 Inhibitor III is a small molecule compound that functions as a selective inhibitor of cyclin-dependent kinase 4 (Cdk4). It exerts its mechanism of action by binding to the ATP-binding site of Cdk4, thereby preventing the phosphorylation of the retinoblastoma protein (Rb) and inhibiting the progression of the cell cycle from G1 to S phase. By targeting Cdk4, disrupts the activity of the cyclin D1-Cdk4 complex, which is for the regulation of cell cycle progression. This inhibition ultimately leads to the suppression of cell proliferation and division. In a development setting, Cdk4 Inhibitor III serves for investigating the molecular pathways involved in cell cycle regulation and has the potential to contribute to a deeper understanding of the mechanisms underlying cell proliferation and development.


Cdk4 Inhibitor III (CAS 265312-55-8) References

  1. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.  |  FitzGerald, J., et al. 2014. PLoS One. 9: e98891. PMID: 24902048
  2. Small-molecule inhibitors of SETD8 with cellular activity.  |  Blum, G., et al. 2014. ACS Chem Biol. 9: 2471-8. PMID: 25137013
  3. Impact of cyclin-dependent kinase CDK4 inhibition on eryptosis.  |  Lang, E., et al. 2015. Cell Physiol Biochem. 37: 1178-86. PMID: 26418250
  4. Sensitivity Profiles of Human Prostate Cancer Cell Lines to an 80 Kinase Inhibitor Panel.  |  Burke, AJ., et al. 2016. Anticancer Res. 36: 633-41. PMID: 26851018
  5. High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.  |  Ghasemi, F., et al. 2018. Oncotarget. 9: 26064-26071. PMID: 29899842
  6. Identification of ryuvidine as a KDM5A inhibitor.  |  Mitsui, E., et al. 2019. Sci Rep. 9: 9952. PMID: 31289306
  7. Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2.  |  Ali, R., et al. 2021. Cells. 10: PMID: 34073849
  8. Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner.  |  Saeki, N., et al. 2022. J Clin Invest. 132: PMID: 35472067

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cdk4 Inhibitor III, 10 mg

sc-202988
10 mg
$347.00