Cdk4 Antibody (97): sc-136241
- Cdk4 Antibody (97) is a mouse monoclonal IgG1, cited in 5 publications, provided at 50 µg/0.5 ml
- raised against amino acids 1-303 representing full length Cdk4 of rat origin
- recommended for detection of Cdk4 of mouse, rat and human origin by WB, IP and IF
- See Cdk4 (DCS-35): sc-23896 for Cdk4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cdk4 Antibody (97). This work is in progress.
Cdk4 Antibody (97) is a mouse monoclonal IgG1 antibody engineered to detect Cyclin-dependent kinase 4 (Cdk4), also known as CDC2-like kinase 4, in mouse, rat, and human samples. Cdk4 monoclonal antibody (97) targets an epitope spanning amino acids 1-303 of the full-length recombinant rat Cdk4 protein, making anti-Cdk4 antibody (97) suitable for applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cdk4 is a crucial serine/threonine kinase that plays a significant role in regulating the cell cycle, particularly the transition from the G1 phase to the S phase, by forming complexes with D-type cyclins. The localization of Cdk4 within the cell, primarily in the nucleus and cytoplasm, is essential for function, as Cdk4 must access and phosphorylate key substrates like the retinoblastoma protein (Rb) to drive cell cycle progression and cellular proliferation. Proper cellular distribution ensures that Cdk4 effectively controls cell growth, while mislocalization can lead to unchecked cell division, a hallmark of cancerous transformations. Additionally, Cdk4 interacts with regulatory proteins such as the inhibitor p16, which modulates activity to maintain controlled cell cycle progression and prevent tumorigenesis. The dynamic localization and interaction of Cdk4 within different cellular compartments allow for responses to various regulatory signals, ensuring accurate cell cycle regulation. By facilitating the detection of Cdk4′s location and expression levels, anti-Cdk4 antibody (97) provides researchers with essential tools to study cell cycle dynamics and implications in cancer research. Available in both non-conjugated and various conjugated forms, including horseradish peroxidase (HRP) and fluorescent tags, Cdk4 (97) antibody offers versatility to meet diverse experimental needs.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdk4 Antibody (97) | sc-136241 | 50 µg/0.5 ml | $322.00 |