Molecular structure of Cdk2 Inhibitor II, CAS Number: 222035-13-4
Cdk2 Inhibitor II (CAS 222035-13-4)
See product citations (19)
Alternate Names:
Compound 3; Cyclin-Dependent Kinase 2 Inhibitor II
Application:
Cdk2 Inhibitor II is a potent and selective inhibitor of Cdk2
CAS Number:
222035-13-4
Purity:
≥95%
Molecular Weight:
395.20
Molecular Formula:
C14H11BrN4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cdk2 Inhibitor II is a potent, cell-permeable, ATP-competitive, and selective inhibitor of Cdk2. CDK2, a critical regulator of cell cycle progression, plays a significant role in various cellular functions, such as cell cycle arrest, apoptosis, and gene expression. In cell cycle analysis, researchers utilize Cdk2 Inhibitor II to investigate the consequences of CDK2 inhibition on cell cycle progression. Similarly, in apoptosis research, Cdk2 Inhibitor II is employed to explore the effects of inhibiting CDK2 on cell death and survival. Furthermore, in gene expression studies, Cdk2 Inhibitor II is utilized to examine the influence of CDK2 inhibition on gene expression patterns.
Cdk2 Inhibitor II (CAS 222035-13-4) References
- Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors. | Davis, ST., et al. 2001. Science. 291: 134-7. PMID: 11141566
- Decreased cyclin-dependent kinase activity promotes thyroid hormone-dependent tail regression in Rana catesbeiana. | Skirrow, RC. and Helbing, CC. 2007. Cell Tissue Res. 328: 281-9. PMID: 17225171
- Cyclin-dependent kinase inhibitors block erythrocyte invasion and intraerythrocytic development of Babesia bovis in vitro. | Nakamura, K., et al. 2007. Parasitology. 134: 1347-53. PMID: 17634158
- Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage. | Ye, W. and Blain, SW. 2011. Apoptosis. 16: 449-59. PMID: 21336968
- Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events. | Xu, X., et al. 2013. Stem Cell Res. 10: 213-27. PMID: 23305945
- TPPII, MYBBP1A and CDK2 form a protein-protein interaction network. | Nahálková, J. and Tomkinson, B. 2014. Arch Biochem Biophys. 564: 128-35. PMID: 25303791
- Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers. | Yang, CC., et al. 2015. Am J Transl Res. 7: 1009-20. PMID: 26279746
- CDK2 Is Required for the DNA Damage Response During Porcine Early Embryonic Development. | Wang, H. and Kim, NH. 2016. Biol Reprod. 95: 31. PMID: 27307074
- Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma. | Wang, J., et al. 2016. Transl Oncol. 9: 548-556. PMID: 27863310
- CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss. | Teitz, T., et al. 2018. J Exp Med. 215: 1187-1203. PMID: 29514916
- Cyclin E2-CDK2 mediates SAMHD1 phosphorylation to abrogate its restriction of HBV replication in hepatoma cells. | Hu, J., et al. 2018. FEBS Lett. 592: 1893-1904. PMID: 29782647
- Lability in sulfur acidic cultivation medium explains unstable effects of CDK inhibitors on Cyanidioschyzon merolae cell proliferation. | Kobayashi, Y. and Tanaka, K. 2019. J Gen Appl Microbiol. 64: 299-302. PMID: 29899184
- Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt. | Liu, K., et al. 2020. Mol Cell Biol. 40: PMID: 31964753
- Proliferation of bovine endometrial epithelial cells is promoted by prostaglandin E2-PTGER2 signaling through cell cycle regulation. | Liu, B., et al. 2021. Prostaglandins Leukot Essent Fatty Acids. 174: 102362. PMID: 34740034
- Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST. | Schaefer, IM., et al. 2022. Br J Cancer. 127: 2072-2085. PMID: 36175617
Inhibitor of:
Cdk2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdk2 Inhibitor II, 500 µg | sc-221409A | 500 µg | $54.00 | |||
Cdk2 Inhibitor II, 1 mg | sc-221409 | 1 mg | $87.00 | |||
Cdk2 Inhibitor II, 5 mg | sc-221409B | 5 mg | $275.00 | |||
Cdk2 Inhibitor II, 50 mg | sc-221409C | 50 mg | $1224.00 | |||
Cdk2 Inhibitor II, 500 mg | sc-221409D | 500 mg | $6125.00 | |||
Cdk2 Inhibitor II, 1 g | sc-221409E | 1 g | $9180.00 | |||
Cdk2 Inhibitor II, 5 g | sc-221409F | 5 g | $26520.00 |