Cdc25C Antibody (TC-14): sc-56269
- Cdc25C Antibody (TC-14) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-258 of Cdc25C of human origin
- recommended for detection of amino acids 1-150 of Cdc25C of human origin by WB, IP and IF
- See Cdc25C (H-6): sc-13138 for Cdc25C antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cdc25C Antibody (TC-14). This work is in progress.
Cdc25C Antibody (TC-14) is a mouse monoclonal IgG1 antibody that detects Cdc25C in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cdc25C plays a crucial role in the regulation of the cell cycle, particularly in the transition from the G2 phase to mitosis, by dephosphorylating and activating cyclin-dependent kinase 1 (Cdk1). This activation is essential for the proper progression of cell division, as it ensures that cells only enter mitosis when they are fully prepared, thereby maintaining genomic stability. Dysregulation of Cdc25C can lead to uncontrolled cell proliferation and is implicated in various cancers, making Cdc25C a significant target for therapeutic intervention. Anti-Cdc25C antibody (TC-14) provides reliable detection of this vital protein, facilitating research into cell cycle regulation and potential cancer biomarkers.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cdc25C Antibody (TC-14) References:
- The dual specificity phosphatase Cdc25C is a direct target for transcriptional repression by the tumor suppressor p53. | St Clair, S. and Manfredi, JJ. 2006. Cell Cycle. 5: 709-13. PMID: 16582636
- Human Plk4 phosphorylates Cdc25C. | Bonni, S., et al. 2008. Cell Cycle. 7: 545-7. PMID: 18239451
- Recurrent CDC25C mutations drive malignant transformation in FPD/AML. | Yoshimi, A., et al. 2014. Nat Commun. 5: 4770. PMID: 25159113
- CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival. | Galusic, D., et al. 2022. Wien Klin Wochenschr. 134: 83-85. PMID: 32945945
- ESRRA promotes gastric cancer development by regulating the CDC25C/CDK1/CyclinB1 pathway via DSN1. | Li, FN., et al. 2021. Int J Biol Sci. 17: 1909-1924. PMID: 34131395
- CDC25C as a Predictive Biomarker for Immune Checkpoint Inhibitors in Patients With Lung Adenocarcinoma. | Zhang, W., et al. 2022. Front Oncol. 12: 867788. PMID: 35574406
- CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma. | Zhou, C., et al. 2022. Bioengineered. 13: 13089-13107. PMID: 35615982
- CDC25C Protein Expression Correlates with Tumor Differentiation and Clinical Outcomes in Lung Adenocarcinoma. | Stern, E., et al. 2023. Biomedicines. 11: PMID: 36830899
- Discovery of a potent and selective PARP1 degrader promoting cell cycle arrest via intercepting CDC25C-CDK1 axis for treating triple-negative breast cancer. | Wu, Y., et al. 2024. Bioorg Chem. 142: 106952. PMID: 37952486
- Telocinobufagin, a PLK1 suppressor that inhibits tumor growth and metastasis by modulating CDC25c and CTCF in HNSCC cells. | Li, J., et al. 2024. Phytomedicine. 127: 155440. PMID: 38452691
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdc25C Antibody (TC-14) | sc-56269 | 100 µg/ml | $322.00 |