Molecular structure of CDC25 Phosphatase Inhibitor I, BN82002, CAS Number: 396073-89-5
CDC25 Phosphatase Inhibitor I, BN82002 (CAS 396073-89-5)
Alternate Names:
4-(dimethylamino)-2-methoxy-6-[[methyl-[2-(4-nitrophenyl)ethyl]amino]methyl]phenol
Application:
CDC25 Phosphatase Inhibitor I, BN82002 is a cell-permeable ortho-hydroxybenzylamino compound
CAS Number:
396073-89-5
Molecular Weight:
359.4
Molecular Formula:
C19H25N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CDC25 Phosphatase Inhibitor I, BN82002, is a cell-permeable ortho-hydroxybenzylamino compound that has been reported to display antitumor properties. It may act to act as a potent, selective and irreversible inhibitor of the CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6 µM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Reported to display a ~20-fold greater selectivity for CDC25 phosphatases over CD45 tyrosine phosphatase. Also shown to delay cell cycle progression in vitro (IC50 = ~7.2-32.6 µM), and reduces tumor growth in athymic mice xenografted with the human pancreatic cells MIA PaCa-2 (15 mg/kg, i.p. route).
CDC25 Phosphatase Inhibitor I, BN82002 (CAS 396073-89-5) References
- A novel synthetic inhibitor of CDC25 phosphatases: BN82002. | Brezak, MC., et al. 2004. Cancer Res. 64: 3320-5. PMID: 15126376
- Synthesis of small molecule CDC25 phosphatases inhibitors. | Contour-Galcéra, MO., et al. 2004. Bioorg Med Chem Lett. 14: 5809-12. PMID: 15501045
- Mechanisms underlying the pro-survival pathway of p53 in suppressing mitotic death induced by adriamycin. | Lin, YC. and Wang, FF. 2008. Cell Signal. 20: 258-67. PMID: 18006273
- CDC25 inhibitors as anticancer agents are moving forward. | Brezak, MC., et al. 2008. Anticancer Agents Med Chem. 8: 857-62. PMID: 19075568
- Inhibition of overexpressed CDC-25.1 phosphatase activity by flavone in Caenorhabditis elegans. | Kim, KS., et al. 2009. Mol Cells. 27: 345-50. PMID: 19326082
- CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples. | Yamashita, Y., et al. 2010. J Neurooncol. 100: 43-9. PMID: 20217459
- Development of a matrix-assisted laser desorption/ionization-mass spectrometry screening test to evidence reversible and irreversible inhibitors of CDC25 phosphatases. | Sibille, E., et al. 2012. Anal Biochem. 430: 83-91. PMID: 22902804
- LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. | Kim, J., et al. 2015. Nat Commun. 6: 10116. PMID: 26626423
- CDC25 Inhibition in Acute Myeloid Leukemia-A Study of Patient Heterogeneity and the Effects of Different Inhibitors. | Brenner, AK., et al. 2017. Molecules. 22: PMID: 28287460
- Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer. | Liu, JC., et al. 2018. Cell Rep. 23: 112-126. PMID: 29617654
- Anti-inflammatory functions of the CDC25 phosphatase inhibitor BN82002 via targeting AKT2. | Kim, HG., et al. 2019. Biochem Pharmacol. 164: 216-227. PMID: 30980807
- BN82002 alleviated tissue damage of septic mice by reducing inflammatory response through inhibiting AKT2/NF-κB signaling pathway. | Kim, HG., et al. 2022. Biomed Pharmacother. 148: 112740. PMID: 35202908
Inhibitor of:
CD45, and Cdc25.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDC25 Phosphatase Inhibitor I, BN82002, 5 mg | sc-311302 | 5 mg | $230.00 |