Cdc20B Antibody (2F2): sc-517066

Cdc20B Antibody (2F2) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Cdc20B protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Cdc20B antibody (2F2) is available as the non-conjugated format. Cdc20B, consisting of 519 amino acids, is characterized by the presence of seven WD repeats, which are essential for function in cell cycle regulation. These WD repeats form a unique tertiary propeller structure that facilitates protein-protein interactions, allowing Cdc20B to play a critical role in the activation of the anaphase-promoting complex/cyclosome (APC/C), a key regulator of the cell cycle. Proper functioning of Cdc20B is vital for timely progression through mitosis, and dysregulation can lead to various cancers due to improper cell division. The gene encoding Cdc20B is located on human chromosome 5, which is significant as alterations in this chromosome are associated with several genetic disorders, including Cri du chat syndrome and therapy-related acute myelogenous leukemias. Cdc20B monoclonal antibody (2F2) is an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying cell division.

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Cdc20B Antibody (2F2) References:

1. The WD repeat: a common architecture for diverse functions.  |  Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
2. WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.  |  Li, D. and Roberts, R. 2001. Cell Mol Life Sci. 58: 2085-97. PMID: 11814058
3. The WD-40 repeat.  |  van der Voorn, L. and Ploegh, HL. 1992. FEBS Lett. 307: 131-4. PMID: 1644165
4. The ancient regulatory-protein family of WD-repeat proteins.  |  Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199
5. Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.  |  Garcia-Higuera, I., et al. 1996. Biochemistry. 35: 13985-94. PMID: 8909296
6. Folding a WD repeat propeller. Role of highly conserved aspartic acid residues in the G protein beta subunit and Sec13.  |  Garcia-Higuera, I., et al. 1998. J Biol Chem. 273: 9041-9. PMID: 9535892

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cdc20B Antibody (2F2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Cdc20B Antibody (2F2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cdc20B Antibody (2F2) Specifications

Alternate Product Name: Cdc20B

Product Clone Name: 2F2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 416-515

Epitope Target: Cdc20B

Epitope Species: human

Product Reactivity/Detection: Cdc20B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Cdc20B Antibody (2F2): N/A