CD45RC Antibody (IBL-8): sc-59076
- CD45RC Antibody (IBL-8) is a rat monoclonal IgG1 provided at 100 µg/ml
- raised against spleen cells of mouse origin
- recommended for detection of CD45RC of mouse origin by WB, IP, IF and FCM; not recommended for detection of CD4+ T cells
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD45RC Antibody (IBL-8). This work is in progress.
QUICK LINKS
CD45RC Antibody (IBL-8) is a rat monoclonal IgG1 antibody that detects CD45RC in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD45RC, also known as PTPRC, is a transmembrane glycoprotein predominantly expressed in hematopoietic cells, where CD45RC (IBL-8) antibody plays a crucial role in the immune response. CD45RC functions as a phosphotyrosine phosphatase within its conserved intracellular domain, essential for regulating tyrosine phosphorylation events initiated by the T cell receptor (TCR)/CD3 complex. CD45RC interacts with key signaling molecules such as Lck, Fyn, and ZAP-70, which are members of the Src and Syk family of protein tyrosine kinases. These interactions facilitate the initiation of downstream signaling cascades that lead to immune responses. Multiple isoforms of CD45RC, generated through alternative splicing, underscore the complexity of its regulatory mechanisms and highlight its significance in maintaining immune homeostasis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD45RC Antibody (IBL-8) | sc-59076 | 100 µg/ml | $322.00 |