CD45RC Antibody (3H1437): sc-70710

CD45RC Antibody (3H1437) is a mouse monoclonal IgG1 antibody that detects CD45RC in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). CD45RC, also known as PTPRC, is a transmembrane glycoprotein predominantly expressed in hematopoietic cells, where CD45RC (3H1437) monoclonal antibody plays a crucial role in immune signaling. CD45RC is characterized by multiple isoforms generated through alternative splicing of exons 4, 5, and 6, which leads to distinct extracellular domains that can be recognized by specific anti-CD45RC antibody targeting CD45RA, CD45RB, CD45RC, and CD45RO. The intracellular domain of CD45RC remains conserved, housing its essential phosphotyrosine phosphatase activity, which is critical for modulating tyrosine phosphorylation events initiated by the T cell receptor/CD3 complex. This activity is vital for proper T cell functioning, as CD45RC regulates the signaling pathways that lead to T cell activation and proliferation. Notably, CD45RC interacts with key signaling molecules such as Lck, Fyn, and ZAP-70, which are members of the Src and Syk family of protein tyrosine kinases, underscoring its importance in orchestrating immune responses. The ability of CD45RC to modulate these signaling pathways makes CD45RC a significant target for research in immunology and therapeutic interventions.

The preferred CD45RC antibody is CD45RC Antibody (OX22): sc-53049.