CD36 Antibody (SMφ): sc-7309

CD36 Antibody (SMφ) is a mouse monoclonal IgM kappa light chain antibody specifically developed to recognize CD36, also known as platelet glycoprotein 4 (GPIV), fatty acid translocase (FAT), glycoprotein IIIb (GPIIIB), scavenger receptor class B member 3 (SCARB3), and PAS IV. CD36 is a multifunctional membrane glycoprotein prominently located on the surface of platelets, monocytes, and umbilical vein endothelial cells. This strategic cellular localization enables CD36 to interact with a variety of ligands, including collagen, thrombospondin, anionic phospholipids, and oxidized low-density lipoproteins (LDL), facilitating crucial processes such as phagocytosis and lipid metabolism. CD36 mediates interactions essential for maintaining cellular homeostasis, supporting the continuous production of mature spermatozoa, and regulating inflammatory responses. CD36 plays a significant role in cell adhesion, influencing adhesive processes vital for tissue integrity and repair. Mutations in CD36 can lead to platelet glycoprotein deficiency, highlighting CD36′s importance in normal platelet function and hemostasis. Anti-CD36 antibody (SMφ) demonstrates reactivity across mouse, rat, and human species, making CD36 (SMφ) antibody a versatile tool for various experimental applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD36 monoclonal antibody (SMφ) supports advanced research into CD36′s diverse roles in cardiovascular diseases, metabolic disorders, and immune system regulation, thereby providing invaluable insights into both physiological and pathological mechanisms.

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CD36 Antibody (SMφ) References:

1. Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine.  |  Greenwalt, DE., et al. 1992. Blood. 80: 1105-15. PMID: 1381234
2. Macrophage chemotaxis to apoptotic Burkitt's lymphoma cells in vitro: role of CD14 and CD36.  |  Truman, LA., et al. 2004. Immunobiology. 209: 21-30. PMID: 15481137
3. FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts.  |  Pohl, J., et al. 2005. Mol Biol Cell. 16: 24-31. PMID: 15496455
4. Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36.  |  Unno, Y., et al. 2004. Biochem Biophys Res Commun. 325: 151-6. PMID: 15522213
5. CD36 is a sensor of diacylglycerides.  |  Hoebe, K., et al. 2005. Nature. 433: 523-7. PMID: 15690042
6. FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms.  |  Bastie, CC., et al. 2005. J Biol Chem. 280: 14222-9. PMID: 15691844
7. Collagen induces normal signal transduction in platelets deficient in CD36 (platelet glycoprotein IV).  |  Daniel, JL., et al. 1994. Thromb Haemost. 71: 353-6. PMID: 7518098
8. Synthesis, processing, and intracellular transport of CD36 during monocytic differentiation.  |  Alessio, M., et al. 1996. J Biol Chem. 271: 1770-5. PMID: 8576181
9. Identification of a domain (155-183) on CD36 implicated in the phagocytosis of apoptotic neutrophils.  |  Navazo, MD., et al. 1996. J Biol Chem. 271: 15381-5. PMID: 8663130
10. CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells.  |  Dawson, DW., et al. 1997. J Cell Biol. 138: 707-17. PMID: 9245797

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD36 Antibody (SMφ) has 101 citations in a variety of scientific publications.

Primary antibodies like Anti-CD36 Antibody (SMφ) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD36 Antibody (SMφ) Specifications

Alternate Product Name: CD36 molecule

Product Clone Name: SMφ

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: CD36

Epitope Species: human

Product Reactivity/Detection: CD36

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 101 citations in various scientific publications

Available Conjugates/Forms for CD36 Antibody (SMφ): AC: Agarose, AF488: Alexa Fluor^® 488, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin