CD300A Antibody (MEM-260): sc-101318

CD300A Antibody (MEM-260) is a mouse monoclonal IgG1 antibody that detects CD300A protein of human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD300A (MEM-260) antibody is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE). CD300A protein, also known as CMRF35H, IRC1, IRC2, IRp60, or IGSF12, is a 299 amino acid single-pass type I membrane protein primarily localized to the cell membrane, where CD300A plays a crucial role in immune regulation. CD300A contains one immunoglobulin-like V-type domain and is expressed in various immune cells, including mast cells, B-cells, dendritic cells, monocytes, granulocytes, and natural killer (NK) cells. As an inhibitory receptor, CD300A is essential for down-regulating NK cell cytolytic activity and may modulate mast cell degranulation, which is vital for maintaining immune homeostasis and preventing excessive inflammatory responses. CD300A undergoes post-translational modifications such as phosphorylation and glycosylation, which can influence function and interactions with other proteins. CD300A gene is located on human chromosome 17, a region encompassing over 2.5% of the human genome and responsible for encoding more than 1,200 genes, highlighting CD300A importance in immune system regulation.

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CD300A Antibody (MEM-260) References:

1. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17.  |  Clark, GJ., et al. 2000. Tissue Antigens. 55: 101-9. PMID: 10746781
2. CMRF-35A, CMRF-35H: potential new CD.  |  Clark, GJ., et al. 2002. J Biol Regul Homeost Agents. 16: 233-5. PMID: 12456026
3. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor.  |  Jackson, DG., et al. 1992. Eur J Immunol. 22: 1157-63. PMID: 1349532
4. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells.  |  Bachelet, I., et al. 2005. J Immunol. 175: 7989-95. PMID: 16339535
5. The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling.  |  Alvarez, Y., et al. 2008. Mol Immunol. 45: 253-8. PMID: 17588661
6. Suppression of normal and malignant kit signaling by a bispecific antibody linking kit with CD300a.  |  Bachelet, I., et al. 2008. J Immunol. 180: 6064-9. PMID: 18424727
7. CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands.  |  Ju, X., et al. 2008. Blood. 112: 1184-94. PMID: 18535206
8. The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor.  |  Green, BJ., et al. 1998. Int Immunol. 10: 891-9. PMID: 9701027

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD300A Antibody (MEM-260) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CD300A Antibody (MEM-260) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD300A Antibody (MEM-260) Specifications

Alternate Product Name: CD300A

Product Clone Name: MEM-260

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CD300A

Epitope Species: human

Product Reactivity/Detection: CD300A

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CD300A Antibody (MEM-260): PE: Phycoerythrin