CD28 Antibody (PV-1): sc-52472
- CD28 Antibody (PV-1) is a Armenian hamster monoclonal IgG, cited in 1 publications, provided at 200 µg/ml
- recommended for detection of CD28 of mouse origin by IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD28 Antibody (PV-1). This work is in progress.
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CD28 Antibody (PV-1) is a hamster monoclonal IgG antibody that detects CD28 in mouse samples through immunoprecipitation (IP) and flow cytometry (FCM) applications. CD28 plays a crucial role in T cell activation and survival by providing essential co-stimulatory signals upon binding to CD80 and CD86 ligands, which are expressed on antigen-presenting cells. Anti-CD28 antibody (PV-1) enhances T cell proliferation and cytokine production, ultimately influencing the adaptive immune response. CD28 is predominantly expressed on resting T cells, while CTLA-4 emerges on activated T cells, serving as a negative regulator of T cell responses. The balance between CD28 and CTLA-4 signaling is critical for maintaining immune homeostasis and preventing autoimmunity. CD28′s ability to interact with other proteins, such as SLAM, which enhances T cell expansion independently of CD28, underscores CD28′s importance in modulating T cell responses. CD28 monoclonal antibody (PV-1) is an essential tool for researchers studying T cell biology and the mechanisms underlying immune regulation.
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CD28 Antibody (PV-1) References:
- T cell co-stimulatory molecules other than CD28. | Watts, TH. and DeBenedette, MA. 1999. Curr Opin Immunol. 11: 286-93. PMID: 10375549
- Control of autoimmune diseases by the B7-CD28 family molecules. | Anand, S. and Chen, L. 2004. Curr Pharm Des. 10: 121-8. PMID: 14754392
- CD28 costimulation regulates genome-wide effects on alternative splicing. | Butte, MJ., et al. 2012. PLoS One. 7: e40032. PMID: 22768209
- CD28 aptamers as powerful immune response modulators. | Pastor, F., et al. 2013. Mol Ther Nucleic Acids. 2: e98. PMID: 23756353
- Disequilibrium in the CD8+CD28+/CD8+CD28- T Lymphocyte Balance Is Related to Prognosis in Rats with Trinitrobenzenesulfonic Acid-Induced Colitis. | Dai, S., et al. 2017. Dig Dis Sci. 62: 639-651. PMID: 28035546
- CD8+CD28+/CD8+CD28- T cell equilibrium can predict the active stage for patients with inflammatory bowel disease. | Dai, SX., et al. 2017. Clin Res Hepatol Gastroenterol. 41: 693-702. PMID: 28502591
- Dynamic regulation of CD28 conformation and signaling by charged lipids and ions. | Yang, W., et al. 2017. Nat Struct Mol Biol. 24: 1081-1092. PMID: 29058713
- Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling. | Skånland, SS. and Taskén, K. 2019. J Immunol. 203: 1055-1063. PMID: 31292214
- CD28- Cells Are Increased in Early Rheumatoid Arthritis and Are Linked With Cytomegalovirus Status. | Thompson, C., et al. 2020. Front Med (Lausanne). 7: 129. PMID: 32432117
- CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells. | Mitra, A., et al. 2020. Front Immunol. 11: 735. PMID: 32457739
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD28 Antibody (PV-1) | sc-52472 | 200 µg/ml | $322.00 | |||
CD28 Antibody (PV-1) FITC | sc-52472 FITC | 200 µg/ml | $336.00 | |||
CD28 Antibody (PV-1) PE | sc-52472 PE | 200 µg/ml | $349.00 |