CD28 Antibody (6A266): sc-70613
- CD28 Antibody (6A266) is a rat monoclonal IgG2b provided at 200 µg/ml
- raised against CD28 of human origin
- recommended for detection of CD28 of human origin by WB, IP, IF and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD28 Antibody (6A266). This work is in progress.
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CD28 Antibody (6A266) is a rat monoclonal IgG2b antibody that detects CD28 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD28 plays a crucial role in T cell activation and survival by providing essential co-stimulatory signals upon binding to CD80 and CD86 ligands, which are expressed on antigen-presenting cells. This interaction is vital for the full activation of T cells, as CD28 enhances proliferation and cytokine production, thereby facilitating an effective immune response. CD28 is predominantly expressed on resting T cells, while CTLA-4 serves as a negative regulator and is upregulated on activated T cells, highlighting the delicate balance of co-stimulatory and inhibitory signals that govern T cell function. Anti-CD28 antibody (6A266) is instrumental in studying these dynamics, allowing researchers to explore the mechanisms of T cell activation and the implications for immunotherapy and autoimmune diseases.
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CD28 Antibody (6A266) References:
- CD28 and T cell co-stimulation. | Holdorf, AD., et al. 2000. Rev Immunogenet. 2: 175-84. PMID: 11258416
- Costimulation of human CD28- T cells by 4-1BB ligand. | Bukczynski, J., et al. 2003. Eur J Immunol. 33: 446-54. PMID: 12645943
- Therapeutic opportunities in the B7/CD28 family of ligands and receptors. | Carreno, BM., et al. 2005. Curr Opin Pharmacol. 5: 424-30. PMID: 15935730
- CD28: old dog, new tricks. CD28 in plasma cell/multiple myeloma biology. | Nair, JR., et al. 2009. Adv Exp Med Biol. 633: 55-69. PMID: 19209681
- Targeting CD4+CD28- T cells by blocking CD28 co-stimulation. | Airò, P. and Scarsi, M. 2013. Trends Mol Med. 19: 1-2. PMID: 23182698
- CD28 and ITK signals regulate autoreactive T cell trafficking. | Jain, N., et al. 2013. Nat Med. 19: 1632-7. PMID: 24270545
- CD28⁻ CD8⁺ T cells are significantly reduced and correlate with disease duration in juveniles with type 1 diabetes. | Yarde, DN., et al. 2014. Hum Immunol. 75: 1069-74. PMID: 25241914
- First report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia. | Youssef, SR. and Elsalakawy, WA. 2021. Hematol Transfus Cell Ther. 43: 396-401. PMID: 32709527
- CD28-CD80/CD86 interactions in testicular immunoregulation. | Sainio-Pöllänen, S., et al. 1996. J Reprod Immunol. 31: 145-63. PMID: 8905549
- CD28, a marker associated with tumoral expansion in multiple myeloma. | Robillard, N., et al. 1998. Clin Cancer Res. 4: 1521-6. PMID: 9626472
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD28 Antibody (6A266) | sc-70613 | 200 µg/ml | $322.00 |