CD27L Antibody (G-7): sc-365539

CD27L Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD27L of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD27L (G-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD27L, a member of the tumor necrosis factor (TNF) receptor family, plays a crucial role in immune responses by providing essential co-stimulatory signals for T cell activation when binding to CD27. This interaction is vital for T cell proliferation and survival, which are key players in adaptive immunity. CD27L expression on antigen-presenting cells enhances T cell activation, thereby promoting effective immune responses against pathogens and tumors. Additionally, CD27L expression regulation can influence immune response outcomes, making CD27L a significant target for therapeutic interventions in various diseases, including cancer and autoimmune disorders. CD27L (G-7) monoclonal antibody serves as an invaluable tool for researchers studying T cell activation mechanisms and broader implications of immune regulation.

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CD27L Antibody (G-7) References:

1. Anti-tumor immunity elicited by a recombinant vaccinia virus expressing CD70 (CD27L).  |  Lorenz, MG., et al. 1999. Hum Gene Ther. 10: 1095-103. PMID: 10340542
2. Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy.  |  Seko, Y., et al. 2002. Cardiovasc Pathol. 11: 166-70. PMID: 12031769
3. The CD27L and CTP1L endolysins targeting Clostridia contain a built-in trigger and release factor.  |  Dunne, M., et al. 2014. PLoS Pathog. 10: e1004228. PMID: 25058163
4. Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH-Wild-Type Glioblastoma.  |  Pratt, D., et al. 2017. J Neuropathol Exp Neurol. 76: 697-708. PMID: 28789475
5. First-in-human study to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of the anti-CD27L antibody-drug conjugate AMG 172 in patients with relapsed/refractory renal cell carcinoma.  |  Massard, C., et al. 2019. Cancer Chemother Pharmacol. 83: 1057-1063. PMID: 30915497
6. CD30 ligand signal transduction involves activation of a tyrosine kinase and of mitogen-activated protein kinase in a Hodgkin's lymphoma cell line.  |  Wendtner, CM., et al. 1995. Cancer Res. 55: 4157-61. PMID: 7545087
7. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas.  |  Gruss, HJ. and Dower, SK. 1995. Blood. 85: 3378-404. PMID: 7780126
8. Tumor necrosis factor receptor superfamily members and their ligands.  |  Armitage, RJ. 1994. Curr Opin Immunol. 6: 407-13. PMID: 7917108
9. CD27: marker and mediator of T-cell activation?  |  Hintzen, RQ., et al. 1994. Immunol Today. 15: 307-11. PMID: 8086099
10. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.  |  Smith, CA., et al. 1993. Cell. 73: 1349-60. PMID: 8391931
11. Structure and expression of murine CD30 and its role in cytokine production.  |  Bowen, MA., et al. 1996. J Immunol. 156: 442-9. PMID: 8543792
12. CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth.  |  Lens, SM., et al. 1995. Leuk Lymphoma. 18: 51-9. PMID: 8580829

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD27L Antibody (G-7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-CD27L Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD27L Antibody (G-7) Specifications

Alternate Product Name: CD27L

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 168-192

Epitope Target: CD27L

Epitope Species: human

Product Reactivity/Detection: CD27L

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for CD27L Antibody (G-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin