CD16 Antibody (LNK16): sc-51524

CD16 Antibody (LNK16) is a mouse monoclonal IgG1 antibody designed to detect human CD16, also known as Fc gamma receptor III (FcγRIII), through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD16 exists in two primary isoforms: CD16A (FcγRIIIA), a transmembrane receptor found on natural killer (NK) cells and macrophages, and CD16B (FcγRIIIB), a glycosylphosphatidylinositol (GPI)-anchored protein present on neutrophils. These isoforms interact with specific proteins essential for their function; for instance, CD16A associates with the γ subunit of FcεRI or the ζ subunit of the TCR-CD3 complex, which are critical for signal transduction and effective immune responses. Additionally, CD16 interacts with signaling molecules such as Syk kinase and PI3K, which play vital roles in mediating antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis. The ability of CD16 to engage with these proteins underscores its pivotal role in immune regulation and response to pathogens. CD16 (LNK16) monoclonal antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, providing flexibility for diverse experimental setups. CD16 (LNK16) antibody is indispensable for research into immune cell function, autoimmune diseases, and conditions like paroxysmal nocturnal hemoglobinuria (PNH), where CD16 expression is significantly altered. With alternate names including FcγRIII, Fc gamma receptor III, CD16A, and CD16B, CD16 (LNK16) monoclonal antibody offers comprehensive detection capabilities, enabling detailed studies of CD16′s interactions and regulatory mechanisms within the immune system.

The preferred CD16 antibody is CD16 Antibody (DJ130c): sc-20052.